Versatile Structurally Diverse Natural Products and Their Semisynthetic Analogs as Potential Antileishmanial Drugs

Patrick O. Sakyi, Richard K. Amewu, Robert N.O.A. Devine, Prakasha Kempaiah, Samuel K. Kwofie

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Mortalities associated with leishmaniasis are skyrocketing at an alarming rate. Lack of vaccine for leishmaniasis treatment is making the fight against the disease an arduous one. Interestingly, apart from the expensive nature of leishmaniasis treatments, the mono-and combinational chemotherapeutic agents suffer drawbacks such as resistance, synergism resistance, systemic toxicity, and ineffectiveness. Due to this, the new paradigm proposed for combating this canker is an efficient therapeutic antileishmanial agent with multitarget inhibitory properties. Though natural products and their derivatives have long been known for their medicinal properties for treating various ailments, little is known for their multimodality antileishmanial effects. A plethora of structurally diverse natural products, their IC50, and their biological targets of inhibition are, therefore, discussed in this book chapter. Structural modifications of these natural products based on pharmacophoric analysis leading to the semi-synthesis of their derivatives are also presented. Additionally, a view on metallodrugs using these versatile natural products and their derivatives coordinated to transition metals geared toward leishmaniasis treatment is proposed.

Original languageEnglish
Title of host publicationNatural Product Based Drug Discovery against Human Parasites
Subtitle of host publicationOpportunities and Challenges
PublisherTaylor and Francis
Pages385-410
Number of pages26
ISBN (Electronic)9789811996054
ISBN (Print)9789811996047
DOIs
Publication statusPublished - 1 Jan 2023

Keywords

  • Chemotherapeutic agents
  • Leishmania parasite
  • Pharmacophoric analysis
  • Synergism resistance
  • Toxicity

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