Unprecedented 22,26-: Seco physalins from Physalis angulata and their anti-inflammatory potential

Cheng Peng Sun; Mahmood Brobbey Oppong; Feng Zhao; Li Xia Chen; Feng Qiu

doi:10.1039/c7ob02205k

Unprecedented 22,26-: Seco physalins from Physalis angulata and their anti-inflammatory potential

Cheng Peng Sun
, Mahmood Brobbey Oppong
, Feng Zhao
, Li Xia Chen
, Feng Qiu

Tianjin University of Traditional Chinese Medicine
Shenyang Pharmaceutical University
Dalian Medical University
Yantai University

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Two novel physalins, including a 22,26-seco physalin, physalin X (1), and a 11,15-cyclo-9(10),14(17),22(26)-triseco physalin with an unprecedented aromatic ring, aromaphysalin B (2), were isolated from Physalis angulata L. Their structures were determined by IR, UV, HRESIMS, and 2D NMR spectra as well as theoretical calculations. Compounds 1 and 2 exhibited inhibitory activities on NO production with IC₅₀ values of 68.50 and 29.69 μM, respectively. A plausible biosynthetic pathway for 2 is also discussed.

Original language	English
Pages (from-to)	8700-8704
Number of pages	5
Journal	Organic and Biomolecular Chemistry
Volume	15
Issue number	41
DOIs	https://doi.org/10.1039/c7ob02205k
Publication status	Published - 2017
Externally published	Yes

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title = "Unprecedented 22,26-: Seco physalins from Physalis angulata and their anti-inflammatory potential",

abstract = "Two novel physalins, including a 22,26-seco physalin, physalin X (1), and a 11,15-cyclo-9(10),14(17),22(26)-triseco physalin with an unprecedented aromatic ring, aromaphysalin B (2), were isolated from Physalis angulata L. Their structures were determined by IR, UV, HRESIMS, and 2D NMR spectra as well as theoretical calculations. Compounds 1 and 2 exhibited inhibitory activities on NO production with IC50 values of 68.50 and 29.69 μM, respectively. A plausible biosynthetic pathway for 2 is also discussed.",

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AU - Sun, Cheng Peng

AU - Oppong, Mahmood Brobbey

AU - Zhao, Feng

AU - Chen, Li Xia

AU - Qiu, Feng

PY - 2017

Y1 - 2017

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AB - Two novel physalins, including a 22,26-seco physalin, physalin X (1), and a 11,15-cyclo-9(10),14(17),22(26)-triseco physalin with an unprecedented aromatic ring, aromaphysalin B (2), were isolated from Physalis angulata L. Their structures were determined by IR, UV, HRESIMS, and 2D NMR spectra as well as theoretical calculations. Compounds 1 and 2 exhibited inhibitory activities on NO production with IC50 values of 68.50 and 29.69 μM, respectively. A plausible biosynthetic pathway for 2 is also discussed.

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JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 41

ER -

Unprecedented 22,26-: Seco physalins from Physalis angulata and their anti-inflammatory potential

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