TY - JOUR
T1 - Unprecedented 22,26-
T2 - Seco physalins from Physalis angulata and their anti-inflammatory potential
AU - Sun, Cheng Peng
AU - Oppong, Mahmood Brobbey
AU - Zhao, Feng
AU - Chen, Li Xia
AU - Qiu, Feng
N1 - Publisher Copyright:
© 2017 The Royal Society of Chemistry.
PY - 2017
Y1 - 2017
N2 - Two novel physalins, including a 22,26-seco physalin, physalin X (1), and a 11,15-cyclo-9(10),14(17),22(26)-triseco physalin with an unprecedented aromatic ring, aromaphysalin B (2), were isolated from Physalis angulata L. Their structures were determined by IR, UV, HRESIMS, and 2D NMR spectra as well as theoretical calculations. Compounds 1 and 2 exhibited inhibitory activities on NO production with IC50 values of 68.50 and 29.69 μM, respectively. A plausible biosynthetic pathway for 2 is also discussed.
AB - Two novel physalins, including a 22,26-seco physalin, physalin X (1), and a 11,15-cyclo-9(10),14(17),22(26)-triseco physalin with an unprecedented aromatic ring, aromaphysalin B (2), were isolated from Physalis angulata L. Their structures were determined by IR, UV, HRESIMS, and 2D NMR spectra as well as theoretical calculations. Compounds 1 and 2 exhibited inhibitory activities on NO production with IC50 values of 68.50 and 29.69 μM, respectively. A plausible biosynthetic pathway for 2 is also discussed.
UR - http://www.scopus.com/inward/record.url?scp=85032446822&partnerID=8YFLogxK
U2 - 10.1039/c7ob02205k
DO - 10.1039/c7ob02205k
M3 - Article
C2 - 28991309
AN - SCOPUS:85032446822
SN - 1477-0520
VL - 15
SP - 8700
EP - 8704
JO - Organic and Biomolecular Chemistry
JF - Organic and Biomolecular Chemistry
IS - 41
ER -