Unprecedented 22,26-: Seco physalins from Physalis angulata and their anti-inflammatory potential

Cheng Peng Sun, Mahmood Brobbey Oppong, Feng Zhao, Li Xia Chen, Feng Qiu

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

Two novel physalins, including a 22,26-seco physalin, physalin X (1), and a 11,15-cyclo-9(10),14(17),22(26)-triseco physalin with an unprecedented aromatic ring, aromaphysalin B (2), were isolated from Physalis angulata L. Their structures were determined by IR, UV, HRESIMS, and 2D NMR spectra as well as theoretical calculations. Compounds 1 and 2 exhibited inhibitory activities on NO production with IC50 values of 68.50 and 29.69 μM, respectively. A plausible biosynthetic pathway for 2 is also discussed.

Original languageEnglish
Pages (from-to)8700-8704
Number of pages5
JournalOrganic and Biomolecular Chemistry
Volume15
Issue number41
DOIs
Publication statusPublished - 2017
Externally publishedYes

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