TY - JOUR
T1 - Understanding the biosynthesis of platelets-derived extracellular vesicles
AU - Antwi-Baffour, Samuel
AU - Adjei, Jonathan
AU - Aryeh, Claudia
AU - Kyeremeh, Ransford
AU - Kyei, Foster
AU - Seidu, Mahmood A.
N1 - Publisher Copyright:
© 2015 The Authors.
PY - 2015/9
Y1 - 2015/9
N2 - Platelet-derived extracellular vesicles (PEVs) are described as sub-cellular vesicles released into circulation upon platelets shear stress, activation, injury, or apoptosis. They are considered as universal biomarkers in a wide range of physiological and pathological processes. They are of tremendous significance for the prediction, diagnosis, and observation of the therapeutic success of many diseases. Understanding their biosynthesis and therefore functional properties would contribute to a better understanding of the pathological mechanisms leading to various diseases in which their levels are raised and they are implicated. The review takes a critical look at the historical background of PEVs, their structural components, the mechanism of their formation, physiological, and exogenous stimuli inducing their release and their detection. It concludes by highlighting on the importance of undertaking in-depth studies into PEVs biosynthesis and subsequently gaining a better understanding of their biological role in general.
AB - Platelet-derived extracellular vesicles (PEVs) are described as sub-cellular vesicles released into circulation upon platelets shear stress, activation, injury, or apoptosis. They are considered as universal biomarkers in a wide range of physiological and pathological processes. They are of tremendous significance for the prediction, diagnosis, and observation of the therapeutic success of many diseases. Understanding their biosynthesis and therefore functional properties would contribute to a better understanding of the pathological mechanisms leading to various diseases in which their levels are raised and they are implicated. The review takes a critical look at the historical background of PEVs, their structural components, the mechanism of their formation, physiological, and exogenous stimuli inducing their release and their detection. It concludes by highlighting on the importance of undertaking in-depth studies into PEVs biosynthesis and subsequently gaining a better understanding of their biological role in general.
KW - Actin
KW - Biomarkers
KW - Centrifugation
KW - Extracellular vesicles
KW - Phosphatidylserine
KW - Phospholipids
UR - http://www.scopus.com/inward/record.url?scp=85015680421&partnerID=8YFLogxK
U2 - 10.1002/iid3.66
DO - 10.1002/iid3.66
M3 - Article
AN - SCOPUS:85015680421
SN - 2050-4527
VL - 3
SP - 133
EP - 140
JO - Immunity, inflammation and disease
JF - Immunity, inflammation and disease
IS - 3
ER -