Therapeutic and Toxic Concentrations of Drugs in Biological Matrices

Seth Kwabena Amponsah; Yashwant V. Pathak

doi:10.1007/978-3-031-12398-6_1

Therapeutic and Toxic Concentrations of Drugs in Biological Matrices

Seth Kwabena Amponsah
, Yashwant V. Pathak

Department of Medical Pharmacology

University of South Florida Health

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Therapeutic drug monitoring (TDM) describes the measurement of chemical parameters of drugs during clinical laboratory testing. TDM aids estimation of the efficacy and safety of drugs, often a determinant of future dosing pattern. It combines knowledge of pharmaceutics, pharmacokinetics, and pharmacodynamics of drugs. TDM typically involves measuring of drug concentration in various biological fluids (matrices). Drug levels can be assayed in blood, urine, hair, tears, etc. The concentration of drugs measured in these matrices helps to estimate whether a drug is within its therapeutic range. Usually, when drug levels in these matrices attain toxic concentrations, it will lead to potential adverse effects, thus the need for documented data on therapeutic and toxic concentrations of drugs in the various biological matrices.

Original language	English
Title of host publication	Recent Advances in Therapeutic Drug Monitoring and Clinical Toxicology
Publisher	Springer International Publishing
Pages	1-7
Number of pages	7
ISBN (Electronic)	9783031123986
ISBN (Print)	9783031123979
DOIs	https://doi.org/10.1007/978-3-031-12398-6_1
Publication status	Published - 1 Jan 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Bioanalysis
Drug levels
Matrices
Pharmacokinetics
Toxic concentration

Access to Document

10.1007/978-3-031-12398-6_1

Cite this

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KW - Matrices

KW - Pharmacokinetics

KW - Toxic concentration

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ER -

Therapeutic and Toxic Concentrations of Drugs in Biological Matrices

Abstract

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Keywords

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