The role of ruthenium complexes in neurological cancer and neurodegenerative diseases

Snehlata Katheria, Daniel Amoako Darko, Bhavya Trivedi, Tanmay Ghosh

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Ruthenium complexes have been recognized as an effective replacement to platinum complexes due to their unique modes of action, larger variety of potential uses, and the ability to conquer the multiple drug resistance. The brain, which has a distinct biological intricacy, regulates a wide range of processes, such as cognitive and behavioural ones. Examples of disruptive disorders that affect this organ include neurodegenerative diseases, which can have a long-term negative impact on patients' quality of life and even result in mortality. Neurodegenerative conditions like Parkinson's and Alzheimer's are raising significant medical and societal concerns as the population ages. Particularly transition metal complexes have drawn interest as prospective cancer therapeutic options that could also function as neuroprotective agents with cytotoxic effects. This chapter discusses the function of ruthenium complexes in neurological disorders. Ruthenium compounds have demonstrated therapeutic potential in biological systems as an alternative to current cancer chemotherapy medications and as a potential neuroprotective agent with less cytotoxic effects. Recent studies suggest that ruthenium-based compounds may reduce motor symptoms in cerebral ischemiareperfusion models, prevent or treat gliomas and other types of brain cancer, and possibly even control nociceptive and inflammatory events such as those that occur in the early stages of Alzheimer's disease. Many of the gaps in our knowledge of ruthenium's profound and complex biological effects and the mechanisms underpinning its therapeutic usage need to be filled in by additional research.

Original languageEnglish
Title of host publicationThe Chemistry of Elements
Subtitle of host publicationRubidium, Tellurium, Ruthenium and Gadolinium
PublisherNova Science Publishers, Inc.
Pages243-258
Number of pages16
ISBN (Electronic)9798891130258
ISBN (Print)9798886979657
Publication statusPublished - 11 Aug 2023

Keywords

  • Alzheimer's disease
  • Neurodegenerative
  • Neurological cancer
  • Ruthenium complexes

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