Abstract
Ruthenium complexes have been recognized as an effective replacement to platinum complexes due to their unique modes of action, larger variety of potential uses, and the ability to conquer the multiple drug resistance. The brain, which has a distinct biological intricacy, regulates a wide range of processes, such as cognitive and behavioural ones. Examples of disruptive disorders that affect this organ include neurodegenerative diseases, which can have a long-term negative impact on patients' quality of life and even result in mortality. Neurodegenerative conditions like Parkinson's and Alzheimer's are raising significant medical and societal concerns as the population ages. Particularly transition metal complexes have drawn interest as prospective cancer therapeutic options that could also function as neuroprotective agents with cytotoxic effects. This chapter discusses the function of ruthenium complexes in neurological disorders. Ruthenium compounds have demonstrated therapeutic potential in biological systems as an alternative to current cancer chemotherapy medications and as a potential neuroprotective agent with less cytotoxic effects. Recent studies suggest that ruthenium-based compounds may reduce motor symptoms in cerebral ischemiareperfusion models, prevent or treat gliomas and other types of brain cancer, and possibly even control nociceptive and inflammatory events such as those that occur in the early stages of Alzheimer's disease. Many of the gaps in our knowledge of ruthenium's profound and complex biological effects and the mechanisms underpinning its therapeutic usage need to be filled in by additional research.
Original language | English |
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Title of host publication | The Chemistry of Elements |
Subtitle of host publication | Rubidium, Tellurium, Ruthenium and Gadolinium |
Publisher | Nova Science Publishers, Inc. |
Pages | 243-258 |
Number of pages | 16 |
ISBN (Electronic) | 9798891130258 |
ISBN (Print) | 9798886979657 |
Publication status | Published - 11 Aug 2023 |
Keywords
- Alzheimer's disease
- Neurodegenerative
- Neurological cancer
- Ruthenium complexes