The role of metformin in tuberculosis control among TB and diabetes mellitus comorbid individuals

Phillip Tetteh; Emelia K. Danso; Stephen Osei-Wusu; Dorothy Yeboah-Manu; Prince Asare

doi:10.3389/fmicb.2025.1549572

The role of metformin in tuberculosis control among TB and diabetes mellitus comorbid individuals

Phillip Tetteh
, Emelia K. Danso
, Stephen Osei-Wusu
, Dorothy Yeboah-Manu
, Prince Asare

University of Ghana

Research output: Contribution to journal › Review article › peer-review

8 Citations (Scopus)

Abstract

Tuberculosis (TB) is a major global health concern, and its control is particularly hindered in patients with comorbidities such as type 2 diabetes mellitus (TBDM). Metformin, a commonly prescribed antidiabetic medication, has gained attention because of its potential role in improving TB treatment outcomes in patients with TBDM. This review aims to assess the role of metformin in TB case management among TBDM comorbid individuals. By reviewing the available literature, we aimed to explore the potential benefits, complications, mechanisms, and considerations surrounding metformin use as an adjunctive therapy for TB treatment. The findings of this review will shed light on current understanding and highlight areas for further investigation.

Original language	English
Article number	1549572
Journal	Frontiers in Microbiology
Volume	16
DOIs	https://doi.org/10.3389/fmicb.2025.1549572
Publication status	Published - 2025
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Mycobacterium tuberculosis
TB-diabetes patients
diabetes
host-directed therapeutics
immunomodulatory
metformin

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10.3389/fmicb.2025.1549572

Cite this

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title = "The role of metformin in tuberculosis control among TB and diabetes mellitus comorbid individuals",

abstract = "Tuberculosis (TB) is a major global health concern, and its control is particularly hindered in patients with comorbidities such as type 2 diabetes mellitus (TBDM). Metformin, a commonly prescribed antidiabetic medication, has gained attention because of its potential role in improving TB treatment outcomes in patients with TBDM. This review aims to assess the role of metformin in TB case management among TBDM comorbid individuals. By reviewing the available literature, we aimed to explore the potential benefits, complications, mechanisms, and considerations surrounding metformin use as an adjunctive therapy for TB treatment. The findings of this review will shed light on current understanding and highlight areas for further investigation.",

keywords = "Mycobacterium tuberculosis, TB-diabetes patients, diabetes, host-directed therapeutics, immunomodulatory, metformin",

author = "Phillip Tetteh and Danso, \{Emelia K.\} and Stephen Osei-Wusu and Dorothy Yeboah-Manu and Prince Asare",

note = "Publisher Copyright: Copyright {\textcopyright} 2025 Tetteh, Danso, Osei-Wusu, Yeboah-Manu and Asare.",

year = "2025",

doi = "10.3389/fmicb.2025.1549572",

language = "English",

volume = "16",

journal = "Frontiers in Microbiology",

issn = "1664-302X",

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}

TY - JOUR

T1 - The role of metformin in tuberculosis control among TB and diabetes mellitus comorbid individuals

AU - Tetteh, Phillip

AU - Danso, Emelia K.

AU - Osei-Wusu, Stephen

AU - Yeboah-Manu, Dorothy

AU - Asare, Prince

PY - 2025

Y1 - 2025

N2 - Tuberculosis (TB) is a major global health concern, and its control is particularly hindered in patients with comorbidities such as type 2 diabetes mellitus (TBDM). Metformin, a commonly prescribed antidiabetic medication, has gained attention because of its potential role in improving TB treatment outcomes in patients with TBDM. This review aims to assess the role of metformin in TB case management among TBDM comorbid individuals. By reviewing the available literature, we aimed to explore the potential benefits, complications, mechanisms, and considerations surrounding metformin use as an adjunctive therapy for TB treatment. The findings of this review will shed light on current understanding and highlight areas for further investigation.

AB - Tuberculosis (TB) is a major global health concern, and its control is particularly hindered in patients with comorbidities such as type 2 diabetes mellitus (TBDM). Metformin, a commonly prescribed antidiabetic medication, has gained attention because of its potential role in improving TB treatment outcomes in patients with TBDM. This review aims to assess the role of metformin in TB case management among TBDM comorbid individuals. By reviewing the available literature, we aimed to explore the potential benefits, complications, mechanisms, and considerations surrounding metformin use as an adjunctive therapy for TB treatment. The findings of this review will shed light on current understanding and highlight areas for further investigation.

KW - Mycobacterium tuberculosis

KW - TB-diabetes patients

KW - diabetes

KW - host-directed therapeutics

KW - immunomodulatory

KW - metformin

UR - https://www.scopus.com/pages/publications/105004427614

U2 - 10.3389/fmicb.2025.1549572

DO - 10.3389/fmicb.2025.1549572

M3 - Review article

AN - SCOPUS:105004427614

SN - 1664-302X

VL - 16

JO - Frontiers in Microbiology

JF - Frontiers in Microbiology

M1 - 1549572

ER -

The role of metformin in tuberculosis control among TB and diabetes mellitus comorbid individuals

Abstract

UN SDGs

Keywords

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