The learning health system imperative in low-resource contexts

Introduction: Learning health system (LHS) development has been described in the highest resource settings, which could suggest that resources are a precondition to LHS formation. Method: We reviewed literature surrounding LHSs in low-resource contexts and used this to inform an argument that LHS activity is critically important in these circumstances. Results: We focus on three key points. First, when resources are scarce, they should not be squandered. Second, local knowledge artifacts have advantages. Finally, LHS emphasis on lasting sociotechnical infrastructure addresses sustainability concerns. Conclusion: We believe LHS formation and activity is more important in low-resource contexts than in their higher resource counterparts. Less path dependence in many low-resource contexts forecasts that LHSs may see their greatest success there.