Abstract
The live oral rotavirus RV1 (Rotarix) vaccine is formulated from the human G1P[8] RIX4414 virus. Based on RIX4414 sequences, T7 expression plasmids were constructed that supported recovery of recombinant RIX4414-like viruses by reverse genetics. These plasmids will advance the study of the RV1 vaccine, possibly allowing improvements to its efficacy.
Original language | English |
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Journal | Microbiology Resource Announcements |
Volume | 12 |
Issue number | 11 |
DOIs | |
Publication status | Published - 2023 |
Externally published | Yes |
Keywords
- RIX4414 virus
- recombinant virus
- reverse genetic analysis
- rotavirus
- vaccines