T7 expression plasmids for producing a recombinant human G1P[8] rotavirus comprising RIX4414 sequences of the RV1 (Rotarix, GSK) vaccine strain

Asha A. Philip, Chantal A. Agbemabiese, Guanghui Yi, John T. Patton

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

The live oral rotavirus RV1 (Rotarix) vaccine is formulated from the human G1P[8] RIX4414 virus. Based on RIX4414 sequences, T7 expression plasmids were constructed that supported recovery of recombinant RIX4414-like viruses by reverse genetics. These plasmids will advance the study of the RV1 vaccine, possibly allowing improvements to its efficacy.

Original languageEnglish
JournalMicrobiology Resource Announcements
Volume12
Issue number11
DOIs
Publication statusPublished - 2023
Externally publishedYes

Keywords

  • RIX4414 virus
  • recombinant virus
  • reverse genetic analysis
  • rotavirus
  • vaccines

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