Synthesis and evaluation of the antimalarial, anticancer, and caspase 3 activities of tetraoxane dimers

Richard K. Amewu; James Chadwick; Afthab Hussain; Somnath Panda; Rinki Rinki; Omar Janneh; Stephen A. Ward; Candel Miguel; Hollie Burrell-Saward; Livia Vivas; Paul M. O'Neill

doi:10.1016/j.bmc.2013.09.047

Synthesis and evaluation of the antimalarial, anticancer, and caspase 3 activities of tetraoxane dimers

Richard K. Amewu, James Chadwick, Afthab Hussain, Somnath Panda, Rinki Rinki, Omar Janneh, Stephen A. Ward, Candel Miguel, Hollie Burrell-Saward, Livia Vivas, Paul M. O'Neill

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

The synthesis of a range of mono spiro and dispiro 1,2,4,5-tetraoxane dimers is described. Selected molecules were examined in in vitro assays to determine their antimalarial and anticancer potential. Our studies reveal that several molecules possess potent nanomolar antimalarial and single digit micromolar antiproliferative IC₅₀s versus colon (HT29-AK and leukemia (HL60) cell lines.

Original language	English
Pages (from-to)	7392-7397
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry
Volume	21
Issue number	23
DOIs	https://doi.org/10.1016/j.bmc.2013.09.047
Publication status	Published - 1 Dec 2013
Externally published	Yes

Keywords

Apoptosis
Leukaemia
Malaria

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmc.2013.09.047

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title = "Synthesis and evaluation of the antimalarial, anticancer, and caspase 3 activities of tetraoxane dimers",

abstract = "The synthesis of a range of mono spiro and dispiro 1,2,4,5-tetraoxane dimers is described. Selected molecules were examined in in vitro assays to determine their antimalarial and anticancer potential. Our studies reveal that several molecules possess potent nanomolar antimalarial and single digit micromolar antiproliferative IC50s versus colon (HT29-AK and leukemia (HL60) cell lines.",

keywords = "Apoptosis, Leukaemia, Malaria",

author = "Amewu, {Richard K.} and James Chadwick and Afthab Hussain and Somnath Panda and Rinki Rinki and Omar Janneh and Ward, {Stephen A.} and Candel Miguel and Hollie Burrell-Saward and Livia Vivas and O'Neill, {Paul M.}",

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doi = "10.1016/j.bmc.2013.09.047",

language = "English",

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journal = "Bioorganic and Medicinal Chemistry",

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TY - JOUR

T1 - Synthesis and evaluation of the antimalarial, anticancer, and caspase 3 activities of tetraoxane dimers

AU - Amewu, Richard K.

AU - Chadwick, James

AU - Hussain, Afthab

AU - Panda, Somnath

AU - Rinki, Rinki

AU - Janneh, Omar

AU - Ward, Stephen A.

AU - Miguel, Candel

AU - Burrell-Saward, Hollie

AU - Vivas, Livia

AU - O'Neill, Paul M.

PY - 2013/12/1

Y1 - 2013/12/1

N2 - The synthesis of a range of mono spiro and dispiro 1,2,4,5-tetraoxane dimers is described. Selected molecules were examined in in vitro assays to determine their antimalarial and anticancer potential. Our studies reveal that several molecules possess potent nanomolar antimalarial and single digit micromolar antiproliferative IC50s versus colon (HT29-AK and leukemia (HL60) cell lines.

AB - The synthesis of a range of mono spiro and dispiro 1,2,4,5-tetraoxane dimers is described. Selected molecules were examined in in vitro assays to determine their antimalarial and anticancer potential. Our studies reveal that several molecules possess potent nanomolar antimalarial and single digit micromolar antiproliferative IC50s versus colon (HT29-AK and leukemia (HL60) cell lines.

KW - Apoptosis

KW - Leukaemia

KW - Malaria

UR - http://www.scopus.com/inward/record.url?scp=84886951141&partnerID=8YFLogxK

U2 - 10.1016/j.bmc.2013.09.047

DO - 10.1016/j.bmc.2013.09.047

M3 - Article

C2 - 24148834

AN - SCOPUS:84886951141

SN - 0968-0896

VL - 21

SP - 7392

EP - 7397

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

IS - 23

ER -

Synthesis and evaluation of the antimalarial, anticancer, and caspase 3 activities of tetraoxane dimers

Abstract

Keywords

UN SDGs

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