Sub-acute toxicity of a hydro-ethanolic whole plant extract of Synedrella nodiflora (L) Gaertn in rats

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4 Citations (Scopus)

Abstract

Objectives: Synedrella nodiflora (L) Gaertn (family Asteraceae) is traditionally used in Ghana for the management of epilepsy, hiccup and threatened abortion. The anticonvulsant and other related neuro-pharmacological effects of a hydro-ethanolic extract in murine models have been established. To this end, we evaluated a sub-acute toxicity of the hydro-ethanolic whole plant extract in rats. Materials and Methods: The effects of a continuous 14-day oral administration of the extract (100, 300 and 1000 mg/kg) on haematological and serum biochemical parameters were measured. Results: The extract produced no mortality in the rats treated during the study period. The extract also did not significantly affect any of the haematological and serum biochemical indices measured. Conclusion: This result suggests that a 14-day oral administration of the hydro-ethanolic extract of Synedrella nodiflora is relatively safe in Sprague-Dawley male rats under the present laboratory conditions.

Original languageEnglish
Pages (from-to)271-275
Number of pages5
JournalInternational Journal of Green Pharmacy
Volume8
Issue number4
DOIs
Publication statusPublished - 1 Oct 2014

Keywords

  • Male rats
  • Synedrella nodiflora
  • sub-acute toxicity

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