TY - JOUR
T1 - Sub-acute toxicity of a hydro-ethanolic whole plant extract of Synedrella nodiflora (L) Gaertn in rats
AU - Adjei, Samuel
AU - Amoateng, Patrick
AU - Osei-Safo, Dorcas
AU - Sasu, Clement
AU - N'guessan, Benoit Banga
AU - Addo, Phyllis
AU - Asiedu-Gyekye, Julius Isaac
PY - 2014/10/1
Y1 - 2014/10/1
N2 - Objectives: Synedrella nodiflora (L) Gaertn (family Asteraceae) is traditionally used in Ghana for the management of epilepsy, hiccup and threatened abortion. The anticonvulsant and other related neuro-pharmacological effects of a hydro-ethanolic extract in murine models have been established. To this end, we evaluated a sub-acute toxicity of the hydro-ethanolic whole plant extract in rats. Materials and Methods: The effects of a continuous 14-day oral administration of the extract (100, 300 and 1000 mg/kg) on haematological and serum biochemical parameters were measured. Results: The extract produced no mortality in the rats treated during the study period. The extract also did not significantly affect any of the haematological and serum biochemical indices measured. Conclusion: This result suggests that a 14-day oral administration of the hydro-ethanolic extract of Synedrella nodiflora is relatively safe in Sprague-Dawley male rats under the present laboratory conditions.
AB - Objectives: Synedrella nodiflora (L) Gaertn (family Asteraceae) is traditionally used in Ghana for the management of epilepsy, hiccup and threatened abortion. The anticonvulsant and other related neuro-pharmacological effects of a hydro-ethanolic extract in murine models have been established. To this end, we evaluated a sub-acute toxicity of the hydro-ethanolic whole plant extract in rats. Materials and Methods: The effects of a continuous 14-day oral administration of the extract (100, 300 and 1000 mg/kg) on haematological and serum biochemical parameters were measured. Results: The extract produced no mortality in the rats treated during the study period. The extract also did not significantly affect any of the haematological and serum biochemical indices measured. Conclusion: This result suggests that a 14-day oral administration of the hydro-ethanolic extract of Synedrella nodiflora is relatively safe in Sprague-Dawley male rats under the present laboratory conditions.
KW - Male rats
KW - Synedrella nodiflora
KW - sub-acute toxicity
UR - http://www.scopus.com/inward/record.url?scp=84908650920&partnerID=8YFLogxK
U2 - 10.4103/0973-8258.142695
DO - 10.4103/0973-8258.142695
M3 - Article
AN - SCOPUS:84908650920
SN - 0973-8258
VL - 8
SP - 271
EP - 275
JO - International Journal of Green Pharmacy
JF - International Journal of Green Pharmacy
IS - 4
ER -