TY - JOUR
T1 - Strategies for formulation of effervescent granules of an herbal product for the management of typhoid fever
AU - Adi-Dako, Ofosua
AU - Kumadoh, Doris
AU - Egbi, Godfred
AU - Okyem, Samuel
AU - Addo, Papa Yaw
AU - Nyarko, Alexander
AU - Osei-Asare, Christina
AU - Oppong, Esther Eshun
AU - Adase, Emmanuel
N1 - Publisher Copyright:
© 2021 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/)
PY - 2021/10
Y1 - 2021/10
N2 - Herbal medicines are currently being adopted as alternatives to orthodox medicines for the management of drugresistant and emerging multidrug-resistant microbial strains of various diseases, including typhoid fever. A herbal decoction, MA 001, manufactured by the Centre for Plant Medicine Research (CPMR), has been used for the treatment of typhoid fever for at least two decades in Ghana with desirable outcomes. MA 001 is formulated from Citrus aurantifolia, Spondias mombin, Latana camara, Bidens pilosa, Trema occidentalis, Psidium guajava, Morinda lucida, Vernonia amygdalina, Persea americana, Paulina pinnatta, Momordia charantia and Cnestis ferruguinea medicinal plants. The low palatability and compliance to treatment due to the bulky nature of the decoction poses challenges in its optimum use. This study sought to design and formulate the therapeutic components of the aqueous herbal decoction of MA 001 into an optimal solid dosage form of effervescent granules to improve the delivery of MA 001 as well as increase patient compliance and convenience of product handling. The methods involved pre-formulation studies on the suitability of effervescent vehicles, formulation and evaluation of effervescent granules for drug excipient interactions using high performance liquid chromatography analysis.
AB - Herbal medicines are currently being adopted as alternatives to orthodox medicines for the management of drugresistant and emerging multidrug-resistant microbial strains of various diseases, including typhoid fever. A herbal decoction, MA 001, manufactured by the Centre for Plant Medicine Research (CPMR), has been used for the treatment of typhoid fever for at least two decades in Ghana with desirable outcomes. MA 001 is formulated from Citrus aurantifolia, Spondias mombin, Latana camara, Bidens pilosa, Trema occidentalis, Psidium guajava, Morinda lucida, Vernonia amygdalina, Persea americana, Paulina pinnatta, Momordia charantia and Cnestis ferruguinea medicinal plants. The low palatability and compliance to treatment due to the bulky nature of the decoction poses challenges in its optimum use. This study sought to design and formulate the therapeutic components of the aqueous herbal decoction of MA 001 into an optimal solid dosage form of effervescent granules to improve the delivery of MA 001 as well as increase patient compliance and convenience of product handling. The methods involved pre-formulation studies on the suitability of effervescent vehicles, formulation and evaluation of effervescent granules for drug excipient interactions using high performance liquid chromatography analysis.
KW - Effervescent granules
KW - Formulation
KW - Herbal medicine
KW - High performance liquid chromatography
KW - Typhoid fever
UR - http://www.scopus.com/inward/record.url?scp=85120866278&partnerID=8YFLogxK
U2 - 10.1016/j.heliyon.2021.e08147
DO - 10.1016/j.heliyon.2021.e08147
M3 - Article
AN - SCOPUS:85120866278
SN - 2405-8440
VL - 7
JO - Heliyon
JF - Heliyon
IS - 10
M1 - e08147
ER -