Strategies for formulation of effervescent granules of an herbal product for the management of typhoid fever

Ofosua Adi-Dako, Doris Kumadoh, Godfred Egbi, Samuel Okyem, Papa Yaw Addo, Alexander Nyarko, Christina Osei-Asare, Esther Eshun Oppong, Emmanuel Adase

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Herbal medicines are currently being adopted as alternatives to orthodox medicines for the management of drugresistant and emerging multidrug-resistant microbial strains of various diseases, including typhoid fever. A herbal decoction, MA 001, manufactured by the Centre for Plant Medicine Research (CPMR), has been used for the treatment of typhoid fever for at least two decades in Ghana with desirable outcomes. MA 001 is formulated from Citrus aurantifolia, Spondias mombin, Latana camara, Bidens pilosa, Trema occidentalis, Psidium guajava, Morinda lucida, Vernonia amygdalina, Persea americana, Paulina pinnatta, Momordia charantia and Cnestis ferruguinea medicinal plants. The low palatability and compliance to treatment due to the bulky nature of the decoction poses challenges in its optimum use. This study sought to design and formulate the therapeutic components of the aqueous herbal decoction of MA 001 into an optimal solid dosage form of effervescent granules to improve the delivery of MA 001 as well as increase patient compliance and convenience of product handling. The methods involved pre-formulation studies on the suitability of effervescent vehicles, formulation and evaluation of effervescent granules for drug excipient interactions using high performance liquid chromatography analysis.

Original languageEnglish
Article numbere08147
JournalHeliyon
Volume7
Issue number10
DOIs
Publication statusPublished - Oct 2021

Keywords

  • Effervescent granules
  • Formulation
  • Herbal medicine
  • High performance liquid chromatography
  • Typhoid fever

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