Spatiotemporal Co-existence of Two Mycobacterium ulcerans Clonal Complexes in the Offin River Valley of Ghana

Araceli Lamelas; Kobina Assan Ampah; Samuel Aboagye; Sarah Kerber; Emelia Danso; Adwoa Asante-Poku; Prince Asare; Julian Parkhill; Simon R. Harris; Gerd Pluschke; Dorothy Yeboah-Manu; Katharina Röltgen

doi:10.1371/journal.pntd.0004856

Spatiotemporal Co-existence of Two Mycobacterium ulcerans Clonal Complexes in the Offin River Valley of Ghana

Araceli Lamelas, Kobina Assan Ampah, Samuel Aboagye, Sarah Kerber, Emelia Danso, Adwoa Asante-Poku, Prince Asare, Julian Parkhill, Simon R. Harris, Gerd Pluschke, Dorothy Yeboah-Manu, Katharina Röltgen

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

In recent years, comparative genome sequence analysis of African Mycobacterium ulcerans strains isolated from Buruli ulcer (BU) lesion specimen has revealed a very limited genetic diversity of closely related isolates and a striking association between genotype and geographical origin of the patients. Here, we compared whole genome sequences of five M. ulcerans strains isolated in 2004 or 2013 from BU lesions of four residents of the Offin river valley with 48 strains isolated between 2002 and 2005 from BU lesions of individuals residing in the Densu river valley of Ghana. While all M. ulcerans isolates from the Densu river valley belonged to the same clonal complex, members of two distinct clonal complexes were found in the Offin river valley over space and time. The Offin strains were closely related to genotypes from either the Densu region or from the Asante Akim North district of Ghana. These results point towards an occasional involvement of a mobile reservoir in the transmission of M. ulcerans, enabling the spread of bacteria across different regions.

Original language	English
Article number	e0004856
Journal	PLoS Neglected Tropical Diseases
Volume	10
Issue number	7
DOIs	https://doi.org/10.1371/journal.pntd.0004856
Publication status	Published - 19 Jul 2016
Externally published	Yes

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Lamelas, A., Ampah, K. A., Aboagye, S., Kerber, S., Danso, E., Asante-Poku, A., Asare, P., Parkhill, J., Harris, S. R., Pluschke, G., Yeboah-Manu, D., & Röltgen, K. (2016). Spatiotemporal Co-existence of Two Mycobacterium ulcerans Clonal Complexes in the Offin River Valley of Ghana. PLoS Neglected Tropical Diseases, 10(7), Article e0004856. https://doi.org/10.1371/journal.pntd.0004856

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title = "Spatiotemporal Co-existence of Two Mycobacterium ulcerans Clonal Complexes in the Offin River Valley of Ghana",

abstract = "In recent years, comparative genome sequence analysis of African Mycobacterium ulcerans strains isolated from Buruli ulcer (BU) lesion specimen has revealed a very limited genetic diversity of closely related isolates and a striking association between genotype and geographical origin of the patients. Here, we compared whole genome sequences of five M. ulcerans strains isolated in 2004 or 2013 from BU lesions of four residents of the Offin river valley with 48 strains isolated between 2002 and 2005 from BU lesions of individuals residing in the Densu river valley of Ghana. While all M. ulcerans isolates from the Densu river valley belonged to the same clonal complex, members of two distinct clonal complexes were found in the Offin river valley over space and time. The Offin strains were closely related to genotypes from either the Densu region or from the Asante Akim North district of Ghana. These results point towards an occasional involvement of a mobile reservoir in the transmission of M. ulcerans, enabling the spread of bacteria across different regions.",

author = "Araceli Lamelas and Ampah, {Kobina Assan} and Samuel Aboagye and Sarah Kerber and Emelia Danso and Adwoa Asante-Poku and Prince Asare and Julian Parkhill and Harris, {Simon R.} and Gerd Pluschke and Dorothy Yeboah-Manu and Katharina R{\"o}ltgen",

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Lamelas, A, Ampah, KA, Aboagye, S, Kerber, S, Danso, E, Asante-Poku, A , Asare, P, Parkhill, J, Harris, SR, Pluschke, G, Yeboah-Manu, D & Röltgen, K 2016, 'Spatiotemporal Co-existence of Two Mycobacterium ulcerans Clonal Complexes in the Offin River Valley of Ghana', PLoS Neglected Tropical Diseases, vol. 10, no. 7, e0004856. https://doi.org/10.1371/journal.pntd.0004856

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AU - Kerber, Sarah

AU - Danso, Emelia

AU - Asante-Poku, Adwoa

AU - Asare, Prince

AU - Parkhill, Julian

AU - Harris, Simon R.

AU - Pluschke, Gerd

AU - Yeboah-Manu, Dorothy

AU - Röltgen, Katharina

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AB - In recent years, comparative genome sequence analysis of African Mycobacterium ulcerans strains isolated from Buruli ulcer (BU) lesion specimen has revealed a very limited genetic diversity of closely related isolates and a striking association between genotype and geographical origin of the patients. Here, we compared whole genome sequences of five M. ulcerans strains isolated in 2004 or 2013 from BU lesions of four residents of the Offin river valley with 48 strains isolated between 2002 and 2005 from BU lesions of individuals residing in the Densu river valley of Ghana. While all M. ulcerans isolates from the Densu river valley belonged to the same clonal complex, members of two distinct clonal complexes were found in the Offin river valley over space and time. The Offin strains were closely related to genotypes from either the Densu region or from the Asante Akim North district of Ghana. These results point towards an occasional involvement of a mobile reservoir in the transmission of M. ulcerans, enabling the spread of bacteria across different regions.

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Spatiotemporal Co-existence of Two Mycobacterium ulcerans Clonal Complexes in the Offin River Valley of Ghana

Abstract

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