Setting Our Sights on Infectious Diseases

Manu De Rycker; David Horn; Bree Aldridge; Richard K. Amewu; Clifton E. Barry; Frederick S. Buckner; Sarah Cook; Michael A.J. Ferguson; Nathalie Gobeau; Jennifer Herrmann; Paul Herrling; William Hope; Jennifer Keiser; Maria Jose Lafuente-Monasterio; Paul D. Leeson; Didier Leroy; Ujjini H. Manjunatha; James McCarthy; Timothy J. Miles; Valerie Mizrahi; Olena Moshynets; Jacquin Niles; John P. Overington; John Pottage; Srinivasa P.S. Rao; Kevin D. Read; Isabela Ribeiro; Lynn L. Silver; Jen Southern; Thomas Spangenberg; Shyam Sundar; Caitlin Taylor; Wes Van Voorhis; Nicholas J. White; Susan Wyllie; Paul G. Wyatt; Ian H. Gilbert

doi:10.1021/acsinfecdis.9b00371

Setting Our Sights on Infectious Diseases

Manu De Rycker
, David Horn
, Bree Aldridge
, Richard K. Amewu
, Clifton E. Barry
, Frederick S. Buckner
, Sarah Cook
, Michael A.J. Ferguson
, Nathalie Gobeau
, Jennifer Herrmann
, Paul Herrling
, William Hope
, Jennifer Keiser
, Maria Jose Lafuente-Monasterio
, Paul D. Leeson
, Didier Leroy
, Ujjini H. Manjunatha
, James McCarthy
, Timothy J. Miles
, Valerie Mizrahi

Olena Moshynets, Jacquin Niles, John P. Overington, John Pottage, Srinivasa P.S. Rao, Kevin D. Read, Isabela Ribeiro, Lynn L. Silver, Jen Southern, Thomas Spangenberg, Shyam Sundar, Caitlin Taylor, Wes Van Voorhis, Nicholas J. White, Susan Wyllie, Paul G. Wyatt, Ian H. Gilbert

Department of Chemistry

University of Dundee
Tufts University
US Department of Health and Human Services
University of Washington
University of Glasgow
Medicines for Malaria Venture
Saarland University
Helmholtz Centre for Infection Research
Independent Consultant
University of Liverpool
Swiss Tropical and Public Health Institute Swiss TPH
University of Basel
GlaxoSmithKline
Paul Leeson Consulting Ltd.
Novartis USA
QIMR Berghofer Medical Research Institute
University of Cape Town
Institute of Molecular Biology and Genetics of National Academy of Sciences of Ukraine
Massachusetts Institute of Technology
Medicines Discovery Catapult
ViiV Healthcare
Drugs for Neglected Diseases Initiative
LL Silver Consulting
Lancaster University
Ares Trading SA
Banaras Hindu University, Institute of Medical Sciences
Mahidol-Oxford Tropical Medicine Research Unit

Research output: Contribution to journal › Review article › peer-review

19 Citations (Scopus)

Abstract

In May 2019, the Wellcome Centre for Anti-Infectives Research (WCAIR) at the University of Dundee, UK, held an international conference with the aim of discussing some key questions around discovering new medicines for infectious diseases and a particular focus on diseases affecting Low and Middle Income Countries. There is an urgent need for new drugs to treat most infectious diseases. We were keen to see if there were lessons that we could learn across different disease areas and between the preclinical and clinical phases with the aim of exploring how we can improve and speed up the drug discovery, translational, and clinical development processes. We started with an introductory session on the current situation and then worked backward from clinical development to combination therapy, pharmacokinetic/pharmacodynamic (PK/PD) studies, drug discovery pathways, and new starting points and targets. This Viewpoint aims to capture some of the learnings.

Original language	English
Pages (from-to)	3-13
Number of pages	11
Journal	ACS Infectious Diseases
Volume	6
Issue number	1
DOIs	https://doi.org/10.1021/acsinfecdis.9b00371
Publication status	Published - 10 Jan 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1021/acsinfecdis.9b00371

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De Rycker, M., Horn, D., Aldridge, B., Amewu, R. K., Barry, C. E., Buckner, F. S., Cook, S., Ferguson, M. A. J., Gobeau, N., Herrmann, J., Herrling, P., Hope, W., Keiser, J., Lafuente-Monasterio, M. J., Leeson, P. D., Leroy, D., Manjunatha, U. H., McCarthy, J., Miles, T. J., ... Gilbert, I. H. (2020). Setting Our Sights on Infectious Diseases. ACS Infectious Diseases, 6(1), 3-13. https://doi.org/10.1021/acsinfecdis.9b00371

@article{aa44bdf15b504376ae86e7f789bb3a7e,

title = "Setting Our Sights on Infectious Diseases",

abstract = "In May 2019, the Wellcome Centre for Anti-Infectives Research (WCAIR) at the University of Dundee, UK, held an international conference with the aim of discussing some key questions around discovering new medicines for infectious diseases and a particular focus on diseases affecting Low and Middle Income Countries. There is an urgent need for new drugs to treat most infectious diseases. We were keen to see if there were lessons that we could learn across different disease areas and between the preclinical and clinical phases with the aim of exploring how we can improve and speed up the drug discovery, translational, and clinical development processes. We started with an introductory session on the current situation and then worked backward from clinical development to combination therapy, pharmacokinetic/pharmacodynamic (PK/PD) studies, drug discovery pathways, and new starting points and targets. This Viewpoint aims to capture some of the learnings.",

author = "\{De Rycker\}, Manu and David Horn and Bree Aldridge and Amewu, \{Richard K.\} and Barry, \{Clifton E.\} and Buckner, \{Frederick S.\} and Sarah Cook and Ferguson, \{Michael A.J.\} and Nathalie Gobeau and Jennifer Herrmann and Paul Herrling and William Hope and Jennifer Keiser and Lafuente-Monasterio, \{Maria Jose\} and Leeson, \{Paul D.\} and Didier Leroy and Manjunatha, \{Ujjini H.\} and James McCarthy and Miles, \{Timothy J.\} and Valerie Mizrahi and Olena Moshynets and Jacquin Niles and Overington, \{John P.\} and John Pottage and Rao, \{Srinivasa P.S.\} and Read, \{Kevin D.\} and Isabela Ribeiro and Silver, \{Lynn L.\} and Jen Southern and Thomas Spangenberg and Shyam Sundar and Caitlin Taylor and \{Van Voorhis\}, Wes and White, \{Nicholas J.\} and Susan Wyllie and Wyatt, \{Paul G.\} and Gilbert, \{Ian H.\}",

note = "Publisher Copyright: {\textcopyright} 2019 American Chemical Society.",

year = "2020",

month = jan,

day = "10",

doi = "10.1021/acsinfecdis.9b00371",

language = "English",

volume = "6",

pages = "3--13",

journal = "ACS Infectious Diseases",

issn = "2373-8227",

publisher = "American Chemical Society",

number = "1",

}

De Rycker, M, Horn, D, Aldridge, B, Amewu, RK, Barry, CE, Buckner, FS, Cook, S, Ferguson, MAJ, Gobeau, N, Herrmann, J, Herrling, P, Hope, W, Keiser, J, Lafuente-Monasterio, MJ, Leeson, PD, Leroy, D, Manjunatha, UH, McCarthy, J, Miles, TJ, Mizrahi, V, Moshynets, O, Niles, J, Overington, JP, Pottage, J, Rao, SPS, Read, KD, Ribeiro, I, Silver, LL, Southern, J, Spangenberg, T, Sundar, S, Taylor, C, Van Voorhis, W, White, NJ, Wyllie, S, Wyatt, PG & Gilbert, IH 2020, 'Setting Our Sights on Infectious Diseases', ACS Infectious Diseases, vol. 6, no. 1, pp. 3-13. https://doi.org/10.1021/acsinfecdis.9b00371

TY - JOUR

T1 - Setting Our Sights on Infectious Diseases

AU - De Rycker, Manu

AU - Horn, David

AU - Aldridge, Bree

AU - Amewu, Richard K.

AU - Barry, Clifton E.

AU - Buckner, Frederick S.

AU - Cook, Sarah

AU - Ferguson, Michael A.J.

AU - Gobeau, Nathalie

AU - Herrmann, Jennifer

AU - Herrling, Paul

AU - Hope, William

AU - Keiser, Jennifer

AU - Lafuente-Monasterio, Maria Jose

AU - Leeson, Paul D.

AU - Leroy, Didier

AU - Manjunatha, Ujjini H.

AU - McCarthy, James

AU - Miles, Timothy J.

AU - Mizrahi, Valerie

AU - Moshynets, Olena

AU - Niles, Jacquin

AU - Overington, John P.

AU - Pottage, John

AU - Rao, Srinivasa P.S.

AU - Read, Kevin D.

AU - Ribeiro, Isabela

AU - Silver, Lynn L.

AU - Southern, Jen

AU - Spangenberg, Thomas

AU - Sundar, Shyam

AU - Taylor, Caitlin

AU - Van Voorhis, Wes

AU - White, Nicholas J.

AU - Wyllie, Susan

AU - Wyatt, Paul G.

AU - Gilbert, Ian H.

PY - 2020/1/10

Y1 - 2020/1/10

N2 - In May 2019, the Wellcome Centre for Anti-Infectives Research (WCAIR) at the University of Dundee, UK, held an international conference with the aim of discussing some key questions around discovering new medicines for infectious diseases and a particular focus on diseases affecting Low and Middle Income Countries. There is an urgent need for new drugs to treat most infectious diseases. We were keen to see if there were lessons that we could learn across different disease areas and between the preclinical and clinical phases with the aim of exploring how we can improve and speed up the drug discovery, translational, and clinical development processes. We started with an introductory session on the current situation and then worked backward from clinical development to combination therapy, pharmacokinetic/pharmacodynamic (PK/PD) studies, drug discovery pathways, and new starting points and targets. This Viewpoint aims to capture some of the learnings.

AB - In May 2019, the Wellcome Centre for Anti-Infectives Research (WCAIR) at the University of Dundee, UK, held an international conference with the aim of discussing some key questions around discovering new medicines for infectious diseases and a particular focus on diseases affecting Low and Middle Income Countries. There is an urgent need for new drugs to treat most infectious diseases. We were keen to see if there were lessons that we could learn across different disease areas and between the preclinical and clinical phases with the aim of exploring how we can improve and speed up the drug discovery, translational, and clinical development processes. We started with an introductory session on the current situation and then worked backward from clinical development to combination therapy, pharmacokinetic/pharmacodynamic (PK/PD) studies, drug discovery pathways, and new starting points and targets. This Viewpoint aims to capture some of the learnings.

UR - https://www.scopus.com/pages/publications/85076754483

U2 - 10.1021/acsinfecdis.9b00371

DO - 10.1021/acsinfecdis.9b00371

M3 - Review article

C2 - 31808676

AN - SCOPUS:85076754483

SN - 2373-8227

VL - 6

SP - 3

EP - 13

JO - ACS Infectious Diseases

JF - ACS Infectious Diseases

IS - 1

ER -

Setting Our Sights on Infectious Diseases

Abstract

UN SDGs

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