TY - JOUR
T1 - Serum Potassium, Sodium, and Chloride Levels in Sickle Cell Disease Patients and Healthy Controls
T2 - A Case-Control Study at Korle-Bu Teaching Hospital, Accra
AU - Antwi-Boasiako, Charles
AU - Kusi-Mensah, Yaw A.
AU - Hayfron-Benjamin, Charles
AU - Aryee, Robert
AU - Dankwah, Gifty Boatemaah
AU - Abla, Kwawukume Lim
AU - Owusu Darkwa, Ebenezer
AU - Botchway, Felix Abekah
AU - Sampene-Donkor, Eric
N1 - Publisher Copyright:
© The Author(s) 2019.
PY - 2019
Y1 - 2019
N2 - The activity of Na+-K+ ATPase is altered in sickle cell disease (SCD), which affects serum electrolyte levels. This alteration is associated with several complications in sickle cell patients. This study evaluated the serum levels of sodium, potassium, and chloride in patients with SCD. The study was a case-control cross-sectional study involving 120 SCD patients in the steady state and 48 ‘healthy’ controls. The SCD patients were made up of 69 HbSS patients and 41 HbSC patients. Serum electrolyte levels (Na+, K+, and Cl−) were measured using a Flame Atomic Absorption Spectrometer (Variant 240FS; Varian Australia Pty Ltd). Serum sodium levels were significantly lower in the sickle cell patients, compared with their ‘healthy’ counterparts (P =.0001). Although the study found significantly higher serum levels of potassium in the SCD patients (P =.0001), there was no significant difference in serum chloride levels between patients with SCD and the controls (P =.098). Serum sodium and chloride levels were not significantly different in both HbSS and HbSC patients (P =.197 and P =.553, respectively). The level of serum potassium in the HbSS patients was, however, significantly higher compared with those with the HbSC genotype (P =.0001). There is higher efflux of K+ from the intracellular into the extracellular space in HbSS patients, which may lead to red cell membrane dysfunction and associated complications.
AB - The activity of Na+-K+ ATPase is altered in sickle cell disease (SCD), which affects serum electrolyte levels. This alteration is associated with several complications in sickle cell patients. This study evaluated the serum levels of sodium, potassium, and chloride in patients with SCD. The study was a case-control cross-sectional study involving 120 SCD patients in the steady state and 48 ‘healthy’ controls. The SCD patients were made up of 69 HbSS patients and 41 HbSC patients. Serum electrolyte levels (Na+, K+, and Cl−) were measured using a Flame Atomic Absorption Spectrometer (Variant 240FS; Varian Australia Pty Ltd). Serum sodium levels were significantly lower in the sickle cell patients, compared with their ‘healthy’ counterparts (P =.0001). Although the study found significantly higher serum levels of potassium in the SCD patients (P =.0001), there was no significant difference in serum chloride levels between patients with SCD and the controls (P =.098). Serum sodium and chloride levels were not significantly different in both HbSS and HbSC patients (P =.197 and P =.553, respectively). The level of serum potassium in the HbSS patients was, however, significantly higher compared with those with the HbSC genotype (P =.0001). There is higher efflux of K+ from the intracellular into the extracellular space in HbSS patients, which may lead to red cell membrane dysfunction and associated complications.
KW - Sodium
KW - chloride
KW - potassium
KW - sickle cell disease
UR - http://www.scopus.com/inward/record.url?scp=85073688202&partnerID=8YFLogxK
U2 - 10.1177/1177271919873889
DO - 10.1177/1177271919873889
M3 - Article
AN - SCOPUS:85073688202
SN - 1177-2719
VL - 14
JO - Biomarker Insights
JF - Biomarker Insights
ER -