Selection for simple major surface protein 2 variants during Anaplasma marginale transmission to immunologically naïve animals

Guy H. Palmer; James E. Futse; Christina K. Leverich; Donald P. Knowles; Fred R. Rurangirwa; Kelly A. Brayton

doi:10.1128/IAI.01801-06

Selection for simple major surface protein 2 variants during Anaplasma marginale transmission to immunologically naïve animals

Guy H. Palmer
, James E. Futse
, Christina K. Leverich
, Donald P. Knowles
, Fred R. Rurangirwa
, Kelly A. Brayton

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Anaplasma marginale, a rickettsial pathogen, evades clearance in the animal host by antigenic variation. Under immune selection, A. marginale expresses complex major surface protein 2 mosaics, derived from multiple donor sequences. However, these mosaics have a selective advantage only in the presence of adaptive immunity and are rapidly replaced by simple variants following transmission.

Original language	English
Pages (from-to)	1502-1506
Number of pages	5
Journal	Infection and Immunity
Volume	75
Issue number	3
DOIs	https://doi.org/10.1128/IAI.01801-06
Publication status	Published - Mar 2007
Externally published	Yes

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10.1128/IAI.01801-06

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title = "Selection for simple major surface protein 2 variants during Anaplasma marginale transmission to immunologically na{\"i}ve animals",

abstract = "Anaplasma marginale, a rickettsial pathogen, evades clearance in the animal host by antigenic variation. Under immune selection, A. marginale expresses complex major surface protein 2 mosaics, derived from multiple donor sequences. However, these mosaics have a selective advantage only in the presence of adaptive immunity and are rapidly replaced by simple variants following transmission.",

author = "Palmer, \{Guy H.\} and Futse, \{James E.\} and Leverich, \{Christina K.\} and Knowles, \{Donald P.\} and Rurangirwa, \{Fred R.\} and Brayton, \{Kelly A.\}",

year = "2007",

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AU - Palmer, Guy H.

AU - Futse, James E.

AU - Leverich, Christina K.

AU - Knowles, Donald P.

AU - Rurangirwa, Fred R.

AU - Brayton, Kelly A.

PY - 2007/3

Y1 - 2007/3

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AB - Anaplasma marginale, a rickettsial pathogen, evades clearance in the animal host by antigenic variation. Under immune selection, A. marginale expresses complex major surface protein 2 mosaics, derived from multiple donor sequences. However, these mosaics have a selective advantage only in the presence of adaptive immunity and are rapidly replaced by simple variants following transmission.

UR - https://www.scopus.com/pages/publications/33847752293

U2 - 10.1128/IAI.01801-06

DO - 10.1128/IAI.01801-06

M3 - Article

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AN - SCOPUS:33847752293

SN - 0019-9567

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SP - 1502

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JO - Infection and Immunity

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ER -

Selection for simple major surface protein 2 variants during Anaplasma marginale transmission to immunologically naïve animals

Abstract

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