Abstract
Anaplasma marginale, a rickettsial pathogen, evades clearance in the animal host by antigenic variation. Under immune selection, A. marginale expresses complex major surface protein 2 mosaics, derived from multiple donor sequences. However, these mosaics have a selective advantage only in the presence of adaptive immunity and are rapidly replaced by simple variants following transmission.
Original language | English |
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Pages (from-to) | 1502-1506 |
Number of pages | 5 |
Journal | Infection and Immunity |
Volume | 75 |
Issue number | 3 |
DOIs | |
Publication status | Published - Mar 2007 |
Externally published | Yes |