Selection for simple major surface protein 2 variants during Anaplasma marginale transmission to immunologically naïve animals

Guy H. Palmer, James E. Futse, Christina K. Leverich, Donald P. Knowles, Fred R. Rurangirwa, Kelly A. Brayton

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Anaplasma marginale, a rickettsial pathogen, evades clearance in the animal host by antigenic variation. Under immune selection, A. marginale expresses complex major surface protein 2 mosaics, derived from multiple donor sequences. However, these mosaics have a selective advantage only in the presence of adaptive immunity and are rapidly replaced by simple variants following transmission.

Original languageEnglish
Pages (from-to)1502-1506
Number of pages5
JournalInfection and Immunity
Volume75
Issue number3
DOIs
Publication statusPublished - Mar 2007
Externally publishedYes

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