Second generation analogues of RKA182: Synthetic tetraoxanes with outstanding in vitro and in vivo antimalarial activities

Francesc Marti; James Chadwick; Richard K. Amewu; Hollie Burrell-Saward; Abhishek Srivastava; Stephen A. Ward; Raman Sharma; Neil Berry; Paul M. O'Neill

doi:10.1039/c1md00102g

Second generation analogues of RKA182: Synthetic tetraoxanes with outstanding in vitro and in vivo antimalarial activities

Francesc Marti
, James Chadwick
, Richard K. Amewu
, Hollie Burrell-Saward
, Abhishek Srivastava
, Stephen A. Ward
, Raman Sharma
, Neil Berry
, Paul M. O'Neill

University of Liverpool
London School of Hygiene & Tropical Medicine
Liverpool School of Tropical Medicine

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

A series of polar dispiro-1,2,4,5-tetraoxanes have been designed and synthesized by parallel synthesis. From this series, endoperoxides with activity as low as 0.2 nM have been obtained and representatives of this group have excellent oral activities in the P. berghei ANKA mouse model of malaria.

Original language	English
Pages (from-to)	661-665
Number of pages	5
Journal	MedChemComm
Volume	2
Issue number	7
DOIs	https://doi.org/10.1039/c1md00102g
Publication status	Published - Jul 2011
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1039/c1md00102g

Cite this

@article{b61fc049db6c41ce9214903376fc6606,

title = "Second generation analogues of RKA182: Synthetic tetraoxanes with outstanding in vitro and in vivo antimalarial activities",

abstract = "A series of polar dispiro-1,2,4,5-tetraoxanes have been designed and synthesized by parallel synthesis. From this series, endoperoxides with activity as low as 0.2 nM have been obtained and representatives of this group have excellent oral activities in the P. berghei ANKA mouse model of malaria.",

author = "Francesc Marti and James Chadwick and Amewu, \{Richard K.\} and Hollie Burrell-Saward and Abhishek Srivastava and Ward, \{Stephen A.\} and Raman Sharma and Neil Berry and O'Neill, \{Paul M.\}",

year = "2011",

month = jul,

doi = "10.1039/c1md00102g",

language = "English",

volume = "2",

pages = "661--665",

journal = "MedChemComm",

issn = "2040-2503",

publisher = "Royal Society of Chemistry",

number = "7",

}

TY - JOUR

T1 - Second generation analogues of RKA182

T2 - Synthetic tetraoxanes with outstanding in vitro and in vivo antimalarial activities

AU - Marti, Francesc

AU - Chadwick, James

AU - Amewu, Richard K.

AU - Burrell-Saward, Hollie

AU - Srivastava, Abhishek

AU - Ward, Stephen A.

AU - Sharma, Raman

AU - Berry, Neil

AU - O'Neill, Paul M.

PY - 2011/7

Y1 - 2011/7

N2 - A series of polar dispiro-1,2,4,5-tetraoxanes have been designed and synthesized by parallel synthesis. From this series, endoperoxides with activity as low as 0.2 nM have been obtained and representatives of this group have excellent oral activities in the P. berghei ANKA mouse model of malaria.

AB - A series of polar dispiro-1,2,4,5-tetraoxanes have been designed and synthesized by parallel synthesis. From this series, endoperoxides with activity as low as 0.2 nM have been obtained and representatives of this group have excellent oral activities in the P. berghei ANKA mouse model of malaria.

UR - https://www.scopus.com/pages/publications/79960164924

U2 - 10.1039/c1md00102g

DO - 10.1039/c1md00102g

M3 - Article

AN - SCOPUS:79960164924

SN - 2040-2503

VL - 2

SP - 661

EP - 665

JO - MedChemComm

JF - MedChemComm

IS - 7

ER -

Second generation analogues of RKA182: Synthetic tetraoxanes with outstanding in vitro and in vivo antimalarial activities

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this