Second generation analogues of RKA182: Synthetic tetraoxanes with outstanding in vitro and in vivo antimalarial activities

Francesc Marti, James Chadwick, Richard K. Amewu, Hollie Burrell-Saward, Abhishek Srivastava, Stephen A. Ward, Raman Sharma, Neil Berry, Paul M. O'Neill

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

A series of polar dispiro-1,2,4,5-tetraoxanes have been designed and synthesized by parallel synthesis. From this series, endoperoxides with activity as low as 0.2 nM have been obtained and representatives of this group have excellent oral activities in the P. berghei ANKA mouse model of malaria.

Original languageEnglish
Pages (from-to)661-665
Number of pages5
JournalMedChemComm
Volume2
Issue number7
DOIs
Publication statusPublished - Jul 2011
Externally publishedYes

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