Abstract
A series of polar dispiro-1,2,4,5-tetraoxanes have been designed and synthesized by parallel synthesis. From this series, endoperoxides with activity as low as 0.2 nM have been obtained and representatives of this group have excellent oral activities in the P. berghei ANKA mouse model of malaria.
Original language | English |
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Pages (from-to) | 661-665 |
Number of pages | 5 |
Journal | MedChemComm |
Volume | 2 |
Issue number | 7 |
DOIs | |
Publication status | Published - Jul 2011 |
Externally published | Yes |