Rotavirus vaccine take in infants is associated with secretor status

George E. Armah; Margaret M. Cortese; Francis E. Dennis; Ying Yu; Ardythe L. Morrow; Monica M. McNeal; Kristen D.C. Lewis; Denis A. Awuni; Joseph Armachie; Umesh D. Parashar

doi:10.1093/infdis/jiy573

Rotavirus vaccine take in infants is associated with secretor status

George E. Armah
, Margaret M. Cortese
, Francis E. Dennis
, Ying Yu
, Ardythe L. Morrow
, Monica M. McNeal
, Kristen D.C. Lewis
, Denis A. Awuni
, Joseph Armachie
, Umesh D. Parashar

University of Ghana
Centers for Disease Control and Prevention
Perinatal Institute
Cincinnati Children's Hospital Medical Center
PPD
Ministry of Health, Ghana

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

Rotaviruses bind to enterocytes in a genotype-specific manner via histo-blood group antigens (HBGAs), which are also detectable in saliva. We evaluated antirotavirus immunoglobulin A seroconversion ('vaccine take") among 166 Ghanaian infants after 2-3 doses of G1P[8] rotavirus vaccine during a vaccine trial, by HBGA status from saliva collected at age 4.1 years. Only secretor status was associated with seroconversion: 41% seroconversion for secretors vs 13% for nonsecretors; relative risk, 3.2 (95% confidence interval, 1.2-8.1; P =.016). Neither Lewis antigen nor salivary antigen blood type was associated with seroconversion. Likelihood of "take" for any particular rotavirus vaccine may differ across populations based on HBGAs.

Original language	English
Pages (from-to)	746-749
Number of pages	4
Journal	Journal of Infectious Diseases
Volume	219
Issue number	5
DOIs	https://doi.org/10.1093/infdis/jiy573
Publication status	Published - 15 Feb 2019
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

FUT2
Lewis antigen
rotavirus
secretor
vaccine

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10.1093/infdis/jiy573

Cite this

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title = "Rotavirus vaccine take in infants is associated with secretor status",

abstract = "Rotaviruses bind to enterocytes in a genotype-specific manner via histo-blood group antigens (HBGAs), which are also detectable in saliva. We evaluated antirotavirus immunoglobulin A seroconversion ('vaccine take{"}) among 166 Ghanaian infants after 2-3 doses of G1P[8] rotavirus vaccine during a vaccine trial, by HBGA status from saliva collected at age 4.1 years. Only secretor status was associated with seroconversion: 41\% seroconversion for secretors vs 13\% for nonsecretors; relative risk, 3.2 (95\% confidence interval, 1.2-8.1; P =.016). Neither Lewis antigen nor salivary antigen blood type was associated with seroconversion. Likelihood of {"}take{"} for any particular rotavirus vaccine may differ across populations based on HBGAs.",

keywords = "FUT2, Lewis antigen, rotavirus, secretor, vaccine",

author = "Armah, \{George E.\} and Cortese, \{Margaret M.\} and Dennis, \{Francis E.\} and Ying Yu and Morrow, \{Ardythe L.\} and McNeal, \{Monica M.\} and Lewis, \{Kristen D.C.\} and Awuni, \{Denis A.\} and Joseph Armachie and Parashar, \{Umesh D.\}",

note = "Publisher Copyright: {\textcopyright} Published by Oxford University Press for the Infectious Diseases Society of America 2018.",

year = "2019",

month = feb,

day = "15",

doi = "10.1093/infdis/jiy573",

language = "English",

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TY - JOUR

T1 - Rotavirus vaccine take in infants is associated with secretor status

AU - Armah, George E.

AU - Cortese, Margaret M.

AU - Dennis, Francis E.

AU - Yu, Ying

AU - Morrow, Ardythe L.

AU - McNeal, Monica M.

AU - Lewis, Kristen D.C.

AU - Awuni, Denis A.

AU - Armachie, Joseph

AU - Parashar, Umesh D.

N1 - Publisher Copyright: © Published by Oxford University Press for the Infectious Diseases Society of America 2018.

PY - 2019/2/15

Y1 - 2019/2/15

N2 - Rotaviruses bind to enterocytes in a genotype-specific manner via histo-blood group antigens (HBGAs), which are also detectable in saliva. We evaluated antirotavirus immunoglobulin A seroconversion ('vaccine take") among 166 Ghanaian infants after 2-3 doses of G1P[8] rotavirus vaccine during a vaccine trial, by HBGA status from saliva collected at age 4.1 years. Only secretor status was associated with seroconversion: 41% seroconversion for secretors vs 13% for nonsecretors; relative risk, 3.2 (95% confidence interval, 1.2-8.1; P =.016). Neither Lewis antigen nor salivary antigen blood type was associated with seroconversion. Likelihood of "take" for any particular rotavirus vaccine may differ across populations based on HBGAs.

AB - Rotaviruses bind to enterocytes in a genotype-specific manner via histo-blood group antigens (HBGAs), which are also detectable in saliva. We evaluated antirotavirus immunoglobulin A seroconversion ('vaccine take") among 166 Ghanaian infants after 2-3 doses of G1P[8] rotavirus vaccine during a vaccine trial, by HBGA status from saliva collected at age 4.1 years. Only secretor status was associated with seroconversion: 41% seroconversion for secretors vs 13% for nonsecretors; relative risk, 3.2 (95% confidence interval, 1.2-8.1; P =.016). Neither Lewis antigen nor salivary antigen blood type was associated with seroconversion. Likelihood of "take" for any particular rotavirus vaccine may differ across populations based on HBGAs.

KW - FUT2

KW - Lewis antigen

KW - rotavirus

KW - secretor

KW - vaccine

UR - https://www.scopus.com/pages/publications/85061593639

U2 - 10.1093/infdis/jiy573

DO - 10.1093/infdis/jiy573

M3 - Article

C2 - 30357332

AN - SCOPUS:85061593639

SN - 0022-1899

VL - 219

SP - 746

EP - 749

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 5

ER -

Rotavirus vaccine take in infants is associated with secretor status

Abstract

UN SDGs

Keywords

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