Abstract
Rotaviruses bind to enterocytes in a genotype-specific manner via histo-blood group antigens (HBGAs), which are also detectable in saliva. We evaluated antirotavirus immunoglobulin A seroconversion ('vaccine take") among 166 Ghanaian infants after 2-3 doses of G1P[8] rotavirus vaccine during a vaccine trial, by HBGA status from saliva collected at age 4.1 years. Only secretor status was associated with seroconversion: 41% seroconversion for secretors vs 13% for nonsecretors; relative risk, 3.2 (95% confidence interval, 1.2-8.1; P =.016). Neither Lewis antigen nor salivary antigen blood type was associated with seroconversion. Likelihood of "take" for any particular rotavirus vaccine may differ across populations based on HBGAs.
Original language | English |
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Pages (from-to) | 746-749 |
Number of pages | 4 |
Journal | Journal of Infectious Diseases |
Volume | 219 |
Issue number | 5 |
DOIs | |
Publication status | Published - 15 Feb 2019 |
Externally published | Yes |
Keywords
- FUT2
- Lewis antigen
- rotavirus
- secretor
- vaccine