Rotavirus vaccine take in infants is associated with secretor status

George E. Armah, Margaret M. Cortese, Francis E. Dennis, Ying Yu, Ardythe L. Morrow, Monica M. McNeal, Kristen D.C. Lewis, Denis A. Awuni, Joseph Armachie, Umesh D. Parashar

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

Rotaviruses bind to enterocytes in a genotype-specific manner via histo-blood group antigens (HBGAs), which are also detectable in saliva. We evaluated antirotavirus immunoglobulin A seroconversion ('vaccine take") among 166 Ghanaian infants after 2-3 doses of G1P[8] rotavirus vaccine during a vaccine trial, by HBGA status from saliva collected at age 4.1 years. Only secretor status was associated with seroconversion: 41% seroconversion for secretors vs 13% for nonsecretors; relative risk, 3.2 (95% confidence interval, 1.2-8.1; P =.016). Neither Lewis antigen nor salivary antigen blood type was associated with seroconversion. Likelihood of "take" for any particular rotavirus vaccine may differ across populations based on HBGAs.

Original languageEnglish
Pages (from-to)746-749
Number of pages4
JournalJournal of Infectious Diseases
Volume219
Issue number5
DOIs
Publication statusPublished - 15 Feb 2019
Externally publishedYes

Keywords

  • FUT2
  • Lewis antigen
  • rotavirus
  • secretor
  • vaccine

Fingerprint

Dive into the research topics of 'Rotavirus vaccine take in infants is associated with secretor status'. Together they form a unique fingerprint.

Cite this