TY - JOUR
T1 - Randomized comparison of 3 types of micronutrient supplements for home fortification of complementary foods in Ghana
T2 - Effects on growth and motor development
AU - Adu-Afarwuah, Seth
AU - Lartey, Anna
AU - Brown, Kenneth H.
AU - Zlotkin, Stanley
AU - Briend, André
AU - Dewey, Kathryn G.
PY - 2007/8/1
Y1 - 2007/8/1
N2 - Background: The low micronutrient content of complementary foods is associated with growth faltering in many populations. A potential low-cost solution is the home fortification of complementary foods with Sprinkles (SP) powder, crushable Nutritabs (NT) tablets, or energy-dense (108 kcal/d), fat-based Nutributter (NB). Objective: The objective was to test the hypothesis that multiple micronutrients added to home-prepared complementary foods would increase growth and that the effect would be greatest in the presence of added energy from fat. Design: We randomly assigned 313 Ghanaian infants to receive SP, NT, or NB containing 6, 16, and 19 vitamins and minerals, respectively, daily from 6 to 12 mo of age. We assessed anthropometric status at 6, 9, and 12 mo; micronutrient status at 6 and 12 mo; motor development at 12 mo; and morbidity weekly. Infants (n = 96) not randomly selected for the intervention (nonintervention; NI) were assessed at 12 mo. Results: The groups did not differ significantly at baseline, except that the NB group had a higher proportion of boys and weighed slightly more. The dropout rate (15/313) was low. At 12 mo, after control for initial size, the NB group had a significantly greater weight-for-age z score (WAZ) (-0.49 ± 0.54) and length-for-age z score (LAZ) (-0.20 ± 0.54) than did the NT group (WAZ: -0.67 ± 0.54; LAZ: -0.39 ± 0.54) and the NT and SP groups combined (WAZ:-0.65 ± 0.54; LAZ: -0.38 ± 0.54); the difference with the NI group (WAZ: -0.74 ± 1.1; LAZ: -0.40 ± 1.0) was not significant. A lower percentage of the NI infants (25%) than of the intervention groups (SP: 39%; NT: 36%; NB: 49%) could walk independently by 12 mo. Conclusion: All 3 supplements had positive effects on motor milestone acquisition by 12 mo compared with no intervention, but only NB affected growth.
AB - Background: The low micronutrient content of complementary foods is associated with growth faltering in many populations. A potential low-cost solution is the home fortification of complementary foods with Sprinkles (SP) powder, crushable Nutritabs (NT) tablets, or energy-dense (108 kcal/d), fat-based Nutributter (NB). Objective: The objective was to test the hypothesis that multiple micronutrients added to home-prepared complementary foods would increase growth and that the effect would be greatest in the presence of added energy from fat. Design: We randomly assigned 313 Ghanaian infants to receive SP, NT, or NB containing 6, 16, and 19 vitamins and minerals, respectively, daily from 6 to 12 mo of age. We assessed anthropometric status at 6, 9, and 12 mo; micronutrient status at 6 and 12 mo; motor development at 12 mo; and morbidity weekly. Infants (n = 96) not randomly selected for the intervention (nonintervention; NI) were assessed at 12 mo. Results: The groups did not differ significantly at baseline, except that the NB group had a higher proportion of boys and weighed slightly more. The dropout rate (15/313) was low. At 12 mo, after control for initial size, the NB group had a significantly greater weight-for-age z score (WAZ) (-0.49 ± 0.54) and length-for-age z score (LAZ) (-0.20 ± 0.54) than did the NT group (WAZ: -0.67 ± 0.54; LAZ: -0.39 ± 0.54) and the NT and SP groups combined (WAZ:-0.65 ± 0.54; LAZ: -0.38 ± 0.54); the difference with the NI group (WAZ: -0.74 ± 1.1; LAZ: -0.40 ± 1.0) was not significant. A lower percentage of the NI infants (25%) than of the intervention groups (SP: 39%; NT: 36%; NB: 49%) could walk independently by 12 mo. Conclusion: All 3 supplements had positive effects on motor milestone acquisition by 12 mo compared with no intervention, but only NB affected growth.
KW - Ghana
KW - Home fortification
KW - Infant growth
KW - Motor development
KW - Multiple micronutrient supplements
UR - http://www.scopus.com/inward/record.url?scp=34547861336&partnerID=8YFLogxK
U2 - 10.1093/ajcn/86.2.412
DO - 10.1093/ajcn/86.2.412
M3 - Article
C2 - 17684213
AN - SCOPUS:34547861336
SN - 0002-9165
VL - 86
SP - 412
EP - 420
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
IS - 2
ER -