TY - JOUR
T1 - Pulmonary Function in Adults With Type 2 Diabetes With and Without Obesity
AU - Hayfron-Benjamin, Charles F.
AU - Tei, Ruth Korkor
AU - Osei-Tutu, Josephine Korang
AU - Amo-Nyarko, Tracy
AU - Vormatu, Patience
AU - Ackam, Joana N.
AU - Asante, Gloria Odom
AU - Musah, Latif
AU - Bruce, Anastasia N.K.
AU - Obeng, Kwaku Amponsah
N1 - Publisher Copyright:
© 2023 The Authors
PY - 2023/12
Y1 - 2023/12
N2 - Background: Existing reports show a bidirectional association between type 2 diabetes (T2D) and pulmonary dysfunction. Obesity, which is causally related to both T2D and pulmonary dysfunction, could play an important role in this association. However, this has not been reported. Research Question: What are the associations of measures of obesity with pulmonary function in T2D? Study Design and Methods: This was a cross-sectional study among 464 adults with T2D. Spirometry was performed according to the American Thoracic Society/European Respiratory Society guidelines. The predicted values of the spirometric indices were determined using the Global Lung Function Initiative 2012 equations. The values of FEV1/FVC and FVC were used to categorize pulmonary function patterns as normal, obstructive, restrictive, or mixed. Waist circumference (WC) was measured at the midpoint between the lower margin of the lowest palpable rib and the top of the iliac crest. Results: The mean age, diabetes duration, and female/male ratio of the participants were 55.09 ± 10.45 years, 10.00 ± 7.36 years, and 2:1, respectively. In a multiple linear regression model, WC was a significant predictor of FVC (P =.018) and FEV1/FVC ratio (P =.005), but not FEV1 (P =.472). BMI was a significant predictor of FEV1/FVC ratio (P =.031), but not FEV1 (P =.802) or FVC (P =.129). In a multivariable logistic regression model adjusted for age, sex, socioeconomic status, diabetes duration, glycated hemoglobin, statin use, and smoking pack-years, increasing z score WC was associated with higher odds of restrictive spirometry (OR, 1.32; 95% CI, 1.05-1.66; P =.019) but not airway obstruction (OR, 0.65; 95% CI, 0.42-1.03; P =.067). There were no significant associations of increasing z score BMI with restrictive spirometry (OR, 1.24; 95% CI, 0.98-1.58; P =.075) or airway obstruction (OR, 0.79; 95% CI, 0.51-1.24; P =.305). Interpretation: Increasing WC is associated with restrictive spirometry, independent of conventional diabetes and pulmonary risk factors. Future research could explore the role of the reversal of central obesity on pulmonary function in T2D.
AB - Background: Existing reports show a bidirectional association between type 2 diabetes (T2D) and pulmonary dysfunction. Obesity, which is causally related to both T2D and pulmonary dysfunction, could play an important role in this association. However, this has not been reported. Research Question: What are the associations of measures of obesity with pulmonary function in T2D? Study Design and Methods: This was a cross-sectional study among 464 adults with T2D. Spirometry was performed according to the American Thoracic Society/European Respiratory Society guidelines. The predicted values of the spirometric indices were determined using the Global Lung Function Initiative 2012 equations. The values of FEV1/FVC and FVC were used to categorize pulmonary function patterns as normal, obstructive, restrictive, or mixed. Waist circumference (WC) was measured at the midpoint between the lower margin of the lowest palpable rib and the top of the iliac crest. Results: The mean age, diabetes duration, and female/male ratio of the participants were 55.09 ± 10.45 years, 10.00 ± 7.36 years, and 2:1, respectively. In a multiple linear regression model, WC was a significant predictor of FVC (P =.018) and FEV1/FVC ratio (P =.005), but not FEV1 (P =.472). BMI was a significant predictor of FEV1/FVC ratio (P =.031), but not FEV1 (P =.802) or FVC (P =.129). In a multivariable logistic regression model adjusted for age, sex, socioeconomic status, diabetes duration, glycated hemoglobin, statin use, and smoking pack-years, increasing z score WC was associated with higher odds of restrictive spirometry (OR, 1.32; 95% CI, 1.05-1.66; P =.019) but not airway obstruction (OR, 0.65; 95% CI, 0.42-1.03; P =.067). There were no significant associations of increasing z score BMI with restrictive spirometry (OR, 1.24; 95% CI, 0.98-1.58; P =.075) or airway obstruction (OR, 0.79; 95% CI, 0.51-1.24; P =.305). Interpretation: Increasing WC is associated with restrictive spirometry, independent of conventional diabetes and pulmonary risk factors. Future research could explore the role of the reversal of central obesity on pulmonary function in T2D.
KW - obesity
KW - obstructive airway disease
KW - pulmonary dysfunction
KW - restrictive lung disease
KW - type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=85194568195&partnerID=8YFLogxK
U2 - 10.1016/j.chpulm.2023.100014
DO - 10.1016/j.chpulm.2023.100014
M3 - Article
AN - SCOPUS:85194568195
SN - 2949-7892
VL - 1
JO - CHEST Pulmonary
JF - CHEST Pulmonary
IS - 3
M1 - 100014
ER -