Population data of 23 Y chromosome STR loci for the five major human subpopulations of Ghana

Abban Edward Kofi; Hashom Mohd Hakim; Hussein Omar Khan; Siti Afifah Ismail; Anita Ghansah; Agyemang Adjem David; Nor Fazila Che Mat; Geoffrey Keith Chambers; Hisham Atan Edinur

doi:10.1007/s00414-019-02099-w

Population data of 23 Y chromosome STR loci for the five major human subpopulations of Ghana

Abban Edward Kofi, Hashom Mohd Hakim, Hussein Omar Khan, Siti Afifah Ismail, Anita Ghansah, Agyemang Adjem David, Nor Fazila Che Mat, Geoffrey Keith Chambers, Hisham Atan Edinur

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

In this study, 268 samples for unrelated males belonging to the five major human subpopulation groups in Ghana (Akan, Ewe, Mole-Dagbon, Ga-Dangme and Guang) were genetically characterised for 23 Y chromosome short tandem repeat (STR) loci using the Powerplex® Y23 STR kit. A total of 263 complete haplotypes were recorded of which 258 were unique. The haplotype diversity, discriminating capacity and match probability for the pooled population data were 0.9998, 0.9627 and 0.0039, respectively. The pairwise genetic distance (R_ST) for the Ghanaian datasets and other reference populations deposited in the Y-STR Haplotype Reference Database (YHRD) were estimated and mapped using multidimensional scaling (MDS) plot. The Guang and Ewe were significantly different from the Akan, Mole-Dagbon and Ga-Dangme. However, the five Ghanaian datasets were all plotted close together with other African populations in the MDS data mapping.

Original language	English
Pages (from-to)	1313-1315
Number of pages	3
Journal	International Journal of Legal Medicine
Volume	134
Issue number	4
DOIs	https://doi.org/10.1007/s00414-019-02099-w
Publication status	Published - 1 Jul 2020
Externally published	Yes

Keywords

Forensic science
Ghana
Haplotypes
Population genetics
Y chromosome STR

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title = "Population data of 23 Y chromosome STR loci for the five major human subpopulations of Ghana",

abstract = "In this study, 268 samples for unrelated males belonging to the five major human subpopulation groups in Ghana (Akan, Ewe, Mole-Dagbon, Ga-Dangme and Guang) were genetically characterised for 23 Y chromosome short tandem repeat (STR) loci using the Powerplex{\textregistered} Y23 STR kit. A total of 263 complete haplotypes were recorded of which 258 were unique. The haplotype diversity, discriminating capacity and match probability for the pooled population data were 0.9998, 0.9627 and 0.0039, respectively. The pairwise genetic distance (RST) for the Ghanaian datasets and other reference populations deposited in the Y-STR Haplotype Reference Database (YHRD) were estimated and mapped using multidimensional scaling (MDS) plot. The Guang and Ewe were significantly different from the Akan, Mole-Dagbon and Ga-Dangme. However, the five Ghanaian datasets were all plotted close together with other African populations in the MDS data mapping.",

keywords = "Forensic science, Ghana, Haplotypes, Population genetics, Y chromosome STR",

author = "Kofi, {Abban Edward} and Hakim, {Hashom Mohd} and Khan, {Hussein Omar} and Ismail, {Siti Afifah} and Anita Ghansah and David, {Agyemang Adjem} and Mat, {Nor Fazila Che} and Chambers, {Geoffrey Keith} and Edinur, {Hisham Atan}",

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doi = "10.1007/s00414-019-02099-w",

language = "English",

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T1 - Population data of 23 Y chromosome STR loci for the five major human subpopulations of Ghana

AU - Kofi, Abban Edward

AU - Hakim, Hashom Mohd

AU - Khan, Hussein Omar

AU - Ismail, Siti Afifah

AU - Ghansah, Anita

AU - David, Agyemang Adjem

AU - Mat, Nor Fazila Che

AU - Chambers, Geoffrey Keith

AU - Edinur, Hisham Atan

PY - 2020/7/1

Y1 - 2020/7/1

N2 - In this study, 268 samples for unrelated males belonging to the five major human subpopulation groups in Ghana (Akan, Ewe, Mole-Dagbon, Ga-Dangme and Guang) were genetically characterised for 23 Y chromosome short tandem repeat (STR) loci using the Powerplex® Y23 STR kit. A total of 263 complete haplotypes were recorded of which 258 were unique. The haplotype diversity, discriminating capacity and match probability for the pooled population data were 0.9998, 0.9627 and 0.0039, respectively. The pairwise genetic distance (RST) for the Ghanaian datasets and other reference populations deposited in the Y-STR Haplotype Reference Database (YHRD) were estimated and mapped using multidimensional scaling (MDS) plot. The Guang and Ewe were significantly different from the Akan, Mole-Dagbon and Ga-Dangme. However, the five Ghanaian datasets were all plotted close together with other African populations in the MDS data mapping.

AB - In this study, 268 samples for unrelated males belonging to the five major human subpopulation groups in Ghana (Akan, Ewe, Mole-Dagbon, Ga-Dangme and Guang) were genetically characterised for 23 Y chromosome short tandem repeat (STR) loci using the Powerplex® Y23 STR kit. A total of 263 complete haplotypes were recorded of which 258 were unique. The haplotype diversity, discriminating capacity and match probability for the pooled population data were 0.9998, 0.9627 and 0.0039, respectively. The pairwise genetic distance (RST) for the Ghanaian datasets and other reference populations deposited in the Y-STR Haplotype Reference Database (YHRD) were estimated and mapped using multidimensional scaling (MDS) plot. The Guang and Ewe were significantly different from the Akan, Mole-Dagbon and Ga-Dangme. However, the five Ghanaian datasets were all plotted close together with other African populations in the MDS data mapping.

KW - Forensic science

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KW - Haplotypes

KW - Population genetics

KW - Y chromosome STR

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SP - 1313

EP - 1315

JO - International Journal of Legal Medicine

JF - International Journal of Legal Medicine

IS - 4

ER -

Population data of 23 Y chromosome STR loci for the five major human subpopulations of Ghana

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