Polymorphic variability in the interleukin (IL)-1β promoter conditions susceptibility to severe malarial anemia and functional changes in IL-1β production

Collins Ouma, Gregory C. Davenport, Gordon A. Awandare, Christopher C. Keller, Tom Were, Michael F. Otieno, John M. Vulule, Jeremy Martinson, John M. Ong'echa, Robert E. Ferrell, Douglas J. Perkins

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38 Citations (Scopus)

Abstract

Interleukin (IL)-1β is a cytokine released as part of the innate immune response to Plasmodium falciparum. Because the role played by IL-1β polymorphic variability in conditioning the immunopathogenesis of severe malarial anemia (SMA) remains undefined, relationships between IL-1β promoter variants (-31C/T and -511A/G), SMA (hemoglobin [Hb] level <6.0 g/dL), and circulating IL-1β levels were investigated in children with parasitemia (n = 566) from western Kenya. The IL-1β promoter haplotype -31C/-511A (CA) was associated with increased risk of SMA (Hb level <6.0 g/dL; odds ratio [OR], 1.98 [95% confidence interval {CI}, 1.55-2.27]; P < .05) and reduced circulating IL-1β levels (P < .05). The TA (-31T/-511A) haplotype was nonsignificantly associated with protection against SMA (OR, 0.52 [95% CI, 0.18 -1.16]; P = .11) and elevated IL-1β production (P < .05). Compared with the non-SMA group, children with SMA had significantly lower IL-1β levels and nonsignificant elevations in both IL-1 receptor antagonist (IL-1Ra) and the ratio of IL-1Ra to IL-1β. The results presented demonstrate that variation in IL-1β promoter conditions susceptibility to SMA and functional changes in circulating IL-1β levels.

Original languageEnglish
Pages (from-to)1219-1226
Number of pages8
JournalJournal of Infectious Diseases
Volume198
Issue number8
DOIs
Publication statusPublished - 15 Oct 2008
Externally publishedYes

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