Plasmodium and intestinal parasite perturbations of the infected host's inflammatory responses: A systematic review

Aminata Colle Lo, Babacar Faye, Ben Adu Gyan, Linda Eva Amoah

Research output: Contribution to journalReview articlepeer-review

6 Citations (Scopus)

Abstract

Co-infection of malaria and intestinal parasites is widespread in sub-Saharan Africa and causes severe disease especially among the poorest populations. It has been shown that an intestinal parasite (helminth), mixed intestinal helminth or Plasmodium parasite infection in a human induces a wide range of cytokine responses, including anti-inflammatory, pro-inflammatory as well as regulatory cytokines. Although immunological interactions have been suggested to occur during a concurrent infection of helminths and Plasmodium parasites, different conclusions have been drawn on the influence this co-infection has on cytokine production. This review briefly discusses patterns of selected cytokine (IL-6, IL-8, IL-10, TNF-α and INF-γ) responses associated with infections caused by Plasmodium, intestinal parasites as well as a Plasmodium-helminth co-infection.

Original languageEnglish
Article number387
JournalParasites and Vectors
Volume11
Issue number1
DOIs
Publication statusPublished - 3 Jul 2018
Externally publishedYes

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