TY - JOUR
T1 - Plasmodium and intestinal parasite perturbations of the infected host's inflammatory responses
T2 - A systematic review
AU - Lo, Aminata Colle
AU - Faye, Babacar
AU - Gyan, Ben Adu
AU - Amoah, Linda Eva
N1 - Publisher Copyright:
© 2018 The Author(s).
PY - 2018/7/3
Y1 - 2018/7/3
N2 - Co-infection of malaria and intestinal parasites is widespread in sub-Saharan Africa and causes severe disease especially among the poorest populations. It has been shown that an intestinal parasite (helminth), mixed intestinal helminth or Plasmodium parasite infection in a human induces a wide range of cytokine responses, including anti-inflammatory, pro-inflammatory as well as regulatory cytokines. Although immunological interactions have been suggested to occur during a concurrent infection of helminths and Plasmodium parasites, different conclusions have been drawn on the influence this co-infection has on cytokine production. This review briefly discusses patterns of selected cytokine (IL-6, IL-8, IL-10, TNF-α and INF-γ) responses associated with infections caused by Plasmodium, intestinal parasites as well as a Plasmodium-helminth co-infection.
AB - Co-infection of malaria and intestinal parasites is widespread in sub-Saharan Africa and causes severe disease especially among the poorest populations. It has been shown that an intestinal parasite (helminth), mixed intestinal helminth or Plasmodium parasite infection in a human induces a wide range of cytokine responses, including anti-inflammatory, pro-inflammatory as well as regulatory cytokines. Although immunological interactions have been suggested to occur during a concurrent infection of helminths and Plasmodium parasites, different conclusions have been drawn on the influence this co-infection has on cytokine production. This review briefly discusses patterns of selected cytokine (IL-6, IL-8, IL-10, TNF-α and INF-γ) responses associated with infections caused by Plasmodium, intestinal parasites as well as a Plasmodium-helminth co-infection.
UR - http://www.scopus.com/inward/record.url?scp=85049495484&partnerID=8YFLogxK
U2 - 10.1186/s13071-018-2948-8
DO - 10.1186/s13071-018-2948-8
M3 - Review article
C2 - 29970128
AN - SCOPUS:85049495484
SN - 1756-3305
VL - 11
JO - Parasites and Vectors
JF - Parasites and Vectors
IS - 1
M1 - 387
ER -