Plasma levels of some coagulation parameters in Steady State HBSC disease patients

Mauryne Debola Ajuwon, Edeghonghon Olayemi, Amma Anima Benneh

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Introduction: sickle cell disease is a collection of autosomal recessive genetic disorders. It includes homozygous HbSS and double heterozygote combinations such as HbSC. Central and West Africa bears a significant burden of HbSC disease.

Methods: prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen concentration (FC) and platelet count (PC) weredetermined in 41HbSC and HbSS patientsin steady state along with 40 apparently healthy HbAA controls. One way ANOVA test was used to compare means;p values < 0.05 were considered statistically significant.

Results: there was no significant difference in mean PT for the study groups (p = 0.192). Mean PC was highest in HbSS patients: 445.7 +/- 128.3 X 10 9/ L compared to HbSC: 330.0 +/- 97.7 X 10 9/ L andHbAA:245 +/- 77.7 X 10 9/ L (p= 0.000).Mean APTT was 28.1 +/- 3.8 seconds in controls,24.1+/- 66 seconds in HbSS patients and 21.8 +/- 3.8 seconds in HbSC patients (p = 0.000). Mean FCin HbSS was 1.6 +/- 0.7 g/L , 3.2 +/- 0.6 g/L in HbSC and 2.9 +/- 0.4 g/L in HbAA (p =0.000).

Conclusion: a significant difference exists in PC, APTT and FC in HbSC patients compared to HbSS patients and HbAA controls. Elevated FC and shortened APTT may play a role in complications more characteristic of HbSC such as retinopathy and osteonecrosis. These suggestHbSC is not merely a milder form of HbSS; both diseases should be seen as different entities with regards to approaches for management.

Original languageEnglish
JournalPan African Medical Journal
Volume19
DOIs
Publication statusPublished - 17 Nov 2014

Keywords

  • Coagulation parameters
  • Ghana
  • HbSC disease
  • Steady State

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