Phenotypic evidence of T cell exhaustion and senescence during symptomatic plasmodium falciparum Malaria

Augustina Frimpong, Kwadwo Asamoah Kusi, Dennis Adu-Gyasi, Jones Amponsah, Michael Fokuo Ofori, Wilfred Ndifon

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

T cells play significant roles during Plasmodium falciparum infections. Their regulation of the immune response in symptomatic children with malaria has been deemed necessary to prevent immune associated pathology. In this study, we phenotypically characterized the expression of T cell inhibitory(PD-1, CTLA-4) and senescent markers (CD28(-), CD57) from children with symptomatic malaria, asymptomatic malaria and healthy controls using flow cytometry. We observed increased expression of T cell exhaustion and senescence markers in the symptomatic children compared to the asymptomatic and healthy controls. T cell senescence markers were more highly expressed on CD8 T cells than on CD4 T cells. Asymptomatically infected children had comparable levels of these markers with healthy controls except for CD8+ PD-1+ T cells which were significantly elevated in the asymptomatic children. Also, using multivariate regression analysis, CTLA-4 was the only marker that could predict parasitaemia level. The results suggest that the upregulation of immune exhaustion and senescence markers during symptomatic malaria may affect the effector function of T cells leading to inefficient clearance of parasites, hence the inability to develop sterile immunity to malaria.

Original languageEnglish
Article number1345
JournalFrontiers in Immunology
Volume10
Issue numberJUN
DOIs
Publication statusPublished - 2019

Keywords

  • CD57
  • CTLA-4
  • Exhaustion
  • Immune senescence
  • Malaria
  • PD-1
  • Plasmodium falciparum
  • T-cell

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