Pharmacoepidemiology of antiretroviral drugs in a teaching hospital in Lagos, Nigeria

I. A. Oreagba; S. O. Usman; S. O. Olayemi; K. A. Oshikoya; O. Opanuga; T. A. Adeyemo; O. A. Lesi; A. N. Dodoo; A. S. Akanmu

Pharmacoepidemiology of antiretroviral drugs in a teaching hospital in Lagos, Nigeria

I. A. Oreagba
, S. O. Usman
, S. O. Olayemi
, K. A. Oshikoya
, O. Opanuga
, T. A. Adeyemo
, O. A. Lesi
, A. N. Dodoo
, A. S. Akanmu

Lagos University Teaching Hospital

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

OBJECTIVE: Prescribing, adherence, and adverse drug events to HAART in a large antiretroviral programme in Lagos was evaluated.

DESIGN: A retrospective 5 year open cohort study.

SETTING: The AIDS Prevention Initiative in Nigeria (APIN) clinic at LUTH is one of the United States Presidential Emergency Plan for AIDS Relief (PEP-FAR) funded centers for HIV relief program in Nigeria Participants The case files of 390 patients on HAART and attending the APIN clinic were reviewed sequel to random selection.

MAIN OUTCOME MEASURES: Demographics of the patients and pattern of antiretroviral (ARV) combination drugs prescribed were extracted from their case files. The details of the adverse drug events (ADEs) were extracted from drug toxicity forms regularly filled for each patient. A Chi-square test with Yates correction was used to determine the association between adherence and therapeutic outcome.

RESULTS: A total of 2944 prescriptions were assessed. Zidovudine + lamivudine + nevirapine (35.87%) and stavudine + lamivudine + nevirapine (35.63%) were the most frequently prescribed combinations. Over 2000 ADEs were reported with cough (13.3%), fever (8.75%) and skin rashes (8.01%) being the most frequently reported. Drug adherence was associated with good therapeutic outcome (χ(2) = 115.60, p<0.0001).

CONCLUSIONS: Zidovudine + lamivudine + nevirapine was the most frequently prescribed ARV combination. Cough was the most frequently reported ADE. Interventions aimed at rational prescribing of ARV drugs and improving adherence to antiretroviral drugs is essential for good therapeutic outcome in the treatment of HIV infection.

Original language	English
Pages (from-to)	194-203
Number of pages	10
Journal	Ghana Medical Journal
Volume	48
Issue number	4
Publication status	Published - 1 Dec 2014
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Pharmacoepidemiology
adverse events
antiretroviral drugs
drug adherence

Cite this

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title = "Pharmacoepidemiology of antiretroviral drugs in a teaching hospital in Lagos, Nigeria",

abstract = "OBJECTIVE: Prescribing, adherence, and adverse drug events to HAART in a large antiretroviral programme in Lagos was evaluated.DESIGN: A retrospective 5 year open cohort study.SETTING: The AIDS Prevention Initiative in Nigeria (APIN) clinic at LUTH is one of the United States Presidential Emergency Plan for AIDS Relief (PEP-FAR) funded centers for HIV relief program in Nigeria Participants The case files of 390 patients on HAART and attending the APIN clinic were reviewed sequel to random selection.MAIN OUTCOME MEASURES: Demographics of the patients and pattern of antiretroviral (ARV) combination drugs prescribed were extracted from their case files. The details of the adverse drug events (ADEs) were extracted from drug toxicity forms regularly filled for each patient. A Chi-square test with Yates correction was used to determine the association between adherence and therapeutic outcome.RESULTS: A total of 2944 prescriptions were assessed. Zidovudine + lamivudine + nevirapine (35.87\%) and stavudine + lamivudine + nevirapine (35.63\%) were the most frequently prescribed combinations. Over 2000 ADEs were reported with cough (13.3\%), fever (8.75\%) and skin rashes (8.01\%) being the most frequently reported. Drug adherence was associated with good therapeutic outcome (χ(2) = 115.60, p<0.0001).CONCLUSIONS: Zidovudine + lamivudine + nevirapine was the most frequently prescribed ARV combination. Cough was the most frequently reported ADE. Interventions aimed at rational prescribing of ARV drugs and improving adherence to antiretroviral drugs is essential for good therapeutic outcome in the treatment of HIV infection.",

keywords = "Pharmacoepidemiology, adverse events, antiretroviral drugs, drug adherence",

author = "Oreagba, \{I. A.\} and Usman, \{S. O.\} and Olayemi, \{S. O.\} and Oshikoya, \{K. A.\} and O. Opanuga and Adeyemo, \{T. A.\} and Lesi, \{O. A.\} and Dodoo, \{A. N.\} and Akanmu, \{A. S.\}",

year = "2014",

month = dec,

day = "1",

language = "English",

volume = "48",

pages = "194--203",

journal = "Ghana Medical Journal",

issn = "0016-9560",

publisher = "Ghana Medical Association",

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TY - JOUR

T1 - Pharmacoepidemiology of antiretroviral drugs in a teaching hospital in Lagos, Nigeria

AU - Oreagba, I. A.

AU - Usman, S. O.

AU - Olayemi, S. O.

AU - Oshikoya, K. A.

AU - Opanuga, O.

AU - Adeyemo, T. A.

AU - Lesi, O. A.

AU - Dodoo, A. N.

AU - Akanmu, A. S.

PY - 2014/12/1

Y1 - 2014/12/1

N2 - OBJECTIVE: Prescribing, adherence, and adverse drug events to HAART in a large antiretroviral programme in Lagos was evaluated.DESIGN: A retrospective 5 year open cohort study.SETTING: The AIDS Prevention Initiative in Nigeria (APIN) clinic at LUTH is one of the United States Presidential Emergency Plan for AIDS Relief (PEP-FAR) funded centers for HIV relief program in Nigeria Participants The case files of 390 patients on HAART and attending the APIN clinic were reviewed sequel to random selection.MAIN OUTCOME MEASURES: Demographics of the patients and pattern of antiretroviral (ARV) combination drugs prescribed were extracted from their case files. The details of the adverse drug events (ADEs) were extracted from drug toxicity forms regularly filled for each patient. A Chi-square test with Yates correction was used to determine the association between adherence and therapeutic outcome.RESULTS: A total of 2944 prescriptions were assessed. Zidovudine + lamivudine + nevirapine (35.87%) and stavudine + lamivudine + nevirapine (35.63%) were the most frequently prescribed combinations. Over 2000 ADEs were reported with cough (13.3%), fever (8.75%) and skin rashes (8.01%) being the most frequently reported. Drug adherence was associated with good therapeutic outcome (χ(2) = 115.60, p<0.0001).CONCLUSIONS: Zidovudine + lamivudine + nevirapine was the most frequently prescribed ARV combination. Cough was the most frequently reported ADE. Interventions aimed at rational prescribing of ARV drugs and improving adherence to antiretroviral drugs is essential for good therapeutic outcome in the treatment of HIV infection.

AB - OBJECTIVE: Prescribing, adherence, and adverse drug events to HAART in a large antiretroviral programme in Lagos was evaluated.DESIGN: A retrospective 5 year open cohort study.SETTING: The AIDS Prevention Initiative in Nigeria (APIN) clinic at LUTH is one of the United States Presidential Emergency Plan for AIDS Relief (PEP-FAR) funded centers for HIV relief program in Nigeria Participants The case files of 390 patients on HAART and attending the APIN clinic were reviewed sequel to random selection.MAIN OUTCOME MEASURES: Demographics of the patients and pattern of antiretroviral (ARV) combination drugs prescribed were extracted from their case files. The details of the adverse drug events (ADEs) were extracted from drug toxicity forms regularly filled for each patient. A Chi-square test with Yates correction was used to determine the association between adherence and therapeutic outcome.RESULTS: A total of 2944 prescriptions were assessed. Zidovudine + lamivudine + nevirapine (35.87%) and stavudine + lamivudine + nevirapine (35.63%) were the most frequently prescribed combinations. Over 2000 ADEs were reported with cough (13.3%), fever (8.75%) and skin rashes (8.01%) being the most frequently reported. Drug adherence was associated with good therapeutic outcome (χ(2) = 115.60, p<0.0001).CONCLUSIONS: Zidovudine + lamivudine + nevirapine was the most frequently prescribed ARV combination. Cough was the most frequently reported ADE. Interventions aimed at rational prescribing of ARV drugs and improving adherence to antiretroviral drugs is essential for good therapeutic outcome in the treatment of HIV infection.

KW - Pharmacoepidemiology

KW - adverse events

KW - antiretroviral drugs

KW - drug adherence

UR - https://www.scopus.com/pages/publications/84965084263

M3 - Article

C2 - 25709134

AN - SCOPUS:84965084263

SN - 0016-9560

VL - 48

SP - 194

EP - 203

JO - Ghana Medical Journal

JF - Ghana Medical Journal

IS - 4

ER -

Pharmacoepidemiology of antiretroviral drugs in a teaching hospital in Lagos, Nigeria

Abstract

UN SDGs

Keywords

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