PfRH5 vaccine; from the bench to the vial

Philip Ilani; Prince B. Nyarko; Abdouramane Camara; Lucas N. Amenga-Etego; Yaw Aniweh

doi:10.1038/s41541-025-01137-6

PfRH5 vaccine; from the bench to the vial

Philip Ilani
, Prince B. Nyarko
, Abdouramane Camara
, Lucas N. Amenga-Etego
, Yaw Aniweh

West African Center for Cell Biology of Infectious Pathogens

Research output: Contribution to journal › Review article › peer-review

3 Citations (Scopus)

Abstract

The search for potent malaria vaccine candidate has seen several twists and turns. Here, we provide a perspective on the current state of PfRH5-based malaria vaccine development, the progress, existing challenges, and future research directions. We discuss the clinical trials in endemic regions, immune correlates of protection, prospects of integrating PfRH5 into multi-antigen vaccine strategies and considerations on the onward development/deployment of PfRH5 vaccine from the laboratory to endemic communities.

Original language	English
Article number	82
Journal	npj Vaccines
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/s41541-025-01137-6
Publication status	Published - Dec 2025

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10.1038/s41541-025-01137-6

Cite this

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abstract = "The search for potent malaria vaccine candidate has seen several twists and turns. Here, we provide a perspective on the current state of PfRH5-based malaria vaccine development, the progress, existing challenges, and future research directions. We discuss the clinical trials in endemic regions, immune correlates of protection, prospects of integrating PfRH5 into multi-antigen vaccine strategies and considerations on the onward development/deployment of PfRH5 vaccine from the laboratory to endemic communities.",

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AU - Nyarko, Prince B.

AU - Camara, Abdouramane

AU - Amenga-Etego, Lucas N.

AU - Aniweh, Yaw

PY - 2025/12

Y1 - 2025/12

N2 - The search for potent malaria vaccine candidate has seen several twists and turns. Here, we provide a perspective on the current state of PfRH5-based malaria vaccine development, the progress, existing challenges, and future research directions. We discuss the clinical trials in endemic regions, immune correlates of protection, prospects of integrating PfRH5 into multi-antigen vaccine strategies and considerations on the onward development/deployment of PfRH5 vaccine from the laboratory to endemic communities.

AB - The search for potent malaria vaccine candidate has seen several twists and turns. Here, we provide a perspective on the current state of PfRH5-based malaria vaccine development, the progress, existing challenges, and future research directions. We discuss the clinical trials in endemic regions, immune correlates of protection, prospects of integrating PfRH5 into multi-antigen vaccine strategies and considerations on the onward development/deployment of PfRH5 vaccine from the laboratory to endemic communities.

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ER -

PfRH5 vaccine; from the bench to the vial

Abstract

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