Paradoxically elevated efavirenz concentrations in HIV/tuberculosis- coinfected patients with CYP2B6 516TT genotype on rifampin-containing antituberculous therapy

Awewura Kwara, Margaret Lartey, Kwamena W. Sagoe, Michael H. Court

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)

Abstract

Some individuals have higher efavirenz plasma concentrations during rifampin-containing tuberculosis (TB) therapy, contrary to the expected induction effect of rifampin. Among HIV-infected patients without (n = 38) and with TB on rifampin-containing therapy (n = 18), we tested the hypothesis that drug-gene interaction may explain the highly variable drug interactions. Two-way analysis of variance revealed a significant interaction between CYP2B6 516G→T polymorphism and rifampin-containing therapy, suggesting that efavirenz dose adjustment may need to be individualized on the basis of the patient's genotype.

Original languageEnglish
Pages (from-to)388-390
Number of pages3
JournalAIDS
Volume25
Issue number3
DOIs
Publication statusPublished - 28 Jan 2011

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