Abstract
Some individuals have higher efavirenz plasma concentrations during rifampin-containing tuberculosis (TB) therapy, contrary to the expected induction effect of rifampin. Among HIV-infected patients without (n = 38) and with TB on rifampin-containing therapy (n = 18), we tested the hypothesis that drug-gene interaction may explain the highly variable drug interactions. Two-way analysis of variance revealed a significant interaction between CYP2B6 516G→T polymorphism and rifampin-containing therapy, suggesting that efavirenz dose adjustment may need to be individualized on the basis of the patient's genotype.
Original language | English |
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Pages (from-to) | 388-390 |
Number of pages | 3 |
Journal | AIDS |
Volume | 25 |
Issue number | 3 |
DOIs | |
Publication status | Published - 28 Jan 2011 |