TY - JOUR
T1 - Overexpression of JAKMIP1 associates with Wnt/beta-catenin pathway activation and promotes cancer cell proliferation in vitro
AU - Okai, Isaac
AU - Wang, Lan
AU - Gong, Linlin
AU - Arko-Boham, Benjamin
AU - Hao, Lihong
AU - Zhou, Xin
AU - Qi, Xiaoyu
AU - Hu, Jun
AU - Shao, Shujuan
PY - 2013/4
Y1 - 2013/4
N2 - JAKMIP1 is a member of the recently characterized JAKMIP1 family of proteins. It has been suggested that JAKMIP1 may play a role in various cell programs, such as cytoskeleton rearrangement, cell polarization, intracellular transport or even cell signaling activities. We examined its protein expression in tumor and followed it with a model that captures its impact on activities of some tumor-linked signaling pathways as well as how its upregulation affects cell proliferation. Here, we demonstrate that JAKMIP1 is highly expressed in tumor samples than in normal tissues. Additionally, higher expression of this protein may activate Wnt signaling activity, potentiate beta-catenin accumulation and enhance proliferation of cancer cells.
AB - JAKMIP1 is a member of the recently characterized JAKMIP1 family of proteins. It has been suggested that JAKMIP1 may play a role in various cell programs, such as cytoskeleton rearrangement, cell polarization, intracellular transport or even cell signaling activities. We examined its protein expression in tumor and followed it with a model that captures its impact on activities of some tumor-linked signaling pathways as well as how its upregulation affects cell proliferation. Here, we demonstrate that JAKMIP1 is highly expressed in tumor samples than in normal tissues. Additionally, higher expression of this protein may activate Wnt signaling activity, potentiate beta-catenin accumulation and enhance proliferation of cancer cells.
KW - JAKMIP1
KW - Lung cancer
KW - Wnt
UR - http://www.scopus.com/inward/record.url?scp=84875499494&partnerID=8YFLogxK
U2 - 10.1016/j.biopha.2013.01.003
DO - 10.1016/j.biopha.2013.01.003
M3 - Article
C2 - 23481296
AN - SCOPUS:84875499494
SN - 0753-3322
VL - 67
SP - 228
EP - 234
JO - Biomedicine and Pharmacotherapy
JF - Biomedicine and Pharmacotherapy
IS - 3
ER -