Novel nanocrystal clay materials with potential bone cells growth enhancement or inhibition characteristics in vitro

The application of clay nanocrystals in healing has gained popularity in recent years. T objective of this work was to investigate whether healing clays obtained from different geographi locations could influence differential cell growth. X-ray diffraction analyses of both nanocrys materials revealed orthorhombic chamosite structure with lattice parameters: a =15 Å, b= 8 Å a c=7 Å whereas energy dispersive x-ray results showed the presence of Al, Si, Fe and O in b materials. However the porosity measurements of the two materials revealed different p structures. Both materials were tested on human fetal osteoblast cells and the results show differential cell growth in vitro. The results underscore the significance of pore structures in c response as against the chemical composition or the structure of the material. Future mechanis evaluation would be conducted to better understand the pathways leading to the increased/decrea osteoblast adhesion and proliferation by these materials and possible modification of the cl materials for biomedical applications.