New Antimicrobial Accramycins from Streptomyces sp. MA37 Variant

Aziz Alabed, Kwaku Kyeremeh, Hai Deng

Research output: Contribution to journalArticlepeer-review

Abstract

In our continued desire to isolate more bioactive compounds from the Streptomyces sp. MA37 variant, ΔaccJ, three new accramycin derivatives have been successfully characterised. The structures of accramycin L-N (1–3) were established by high-resolution mass spectrometry and 1D and 2D nuclear magnetic resonance. The antimicrobial evaluation of accramycin L-N against Staphylococcus aureus, Klebsiella pneumoniae, and Enterobacter cloacae showed minimum inhibitory concentration (MIC) values ranging from 0.77 to 13.02 µg/mL. Accramycin L exhibited the most significant activity against S. aureus. In addition, accramycin L-N (1–3) displayed significant activity against K. pneumoniae at the MIC values of 0.81, 0.77, and 0.79 µg/mL, respectively.

Original languageEnglish
Article numberM1754
JournalMolBank
Volume2024
Issue number1
DOIs
Publication statusPublished - Mar 2024

Keywords

  • accramycin
  • antimicrobial activity
  • natural product
  • polyketides
  • Streptomycessp

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