Mycobacterium ulcerans and Buruli Ulcer

Mark Eric Benbow; Belinda Hall; Lydia Mosi; Sophie Roberts; Rachel Simmonds; Heather Williamson Jordan

doi:10.1002/9781118644843.ch44

Mycobacterium ulcerans and Buruli Ulcer

Mark Eric Benbow, Belinda Hall, Lydia Mosi, Sophie Roberts, Rachel Simmonds, Heather Williamson Jordan

Department of Biochemistry, Cell And Molecular Biology

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Citation (Scopus)

Abstract

Buruli Ulcer (BU) is the third most common mycobacterium disease following only tuberculosis and leprosy. Though BU is thought to be associated with large-and small-scale disturbances to the landscape and bodies of water frequented by human populations, primary prevention of BU is difficult because the mode of transmission is not known. This chapter res the most common environmental risk factors for BU and recent research into understanding its transmission. It is predicted that the proteins affected by mycolactone may share an underlying mechanism of production that could explain their co-regulation. Early work on the mechanism of suppression by mycolac-tone was carried out in Jurkat T cells using ASLs and focused on the suppression of IL-2 production. A multidisciplinary approach to treatment and patient care is essential for optimizing treatment outcomes. Physiotherapy is paramount minimizing and/or preventing disabilities.

Original language	English
Title of host publication	Human Emerging and Re-emerging Infections Viral and Parasitic Infections
Subtitle of host publication	Volume 2
Publisher	wiley
Pages	841-861
Number of pages	21
Volume	2
ISBN (Electronic)	9781118644843
ISBN (Print)	9781118644713
DOIs	https://doi.org/10.1002/9781118644843.ch44
Publication status	Published - 1 Jan 2015

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abstract = "Buruli Ulcer (BU) is the third most common mycobacterium disease following only tuberculosis and leprosy. Though BU is thought to be associated with large-and small-scale disturbances to the landscape and bodies of water frequented by human populations, primary prevention of BU is difficult because the mode of transmission is not known. This chapter res the most common environmental risk factors for BU and recent research into understanding its transmission. It is predicted that the proteins affected by mycolactone may share an underlying mechanism of production that could explain their co-regulation. Early work on the mechanism of suppression by mycolac-tone was carried out in Jurkat T cells using ASLs and focused on the suppression of IL-2 production. A multidisciplinary approach to treatment and patient care is essential for optimizing treatment outcomes. Physiotherapy is paramount minimizing and/or preventing disabilities.",

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AU - Benbow, Mark Eric

AU - Hall, Belinda

AU - Mosi, Lydia

AU - Roberts, Sophie

AU - Simmonds, Rachel

AU - Jordan, Heather Williamson

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Mycobacterium ulcerans and Buruli Ulcer

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