TY - JOUR
T1 - Multitargeted Effects of Vitexin and Isovitexin on Diabetes Mellitus and Its Complications
AU - Abdulai, Ibrahim Luru
AU - Kwofie, Samuel Kojo
AU - Gbewonyo, Winfred Seth
AU - Boison, Daniel
AU - Puplampu, Joshua Buer
AU - Adinortey, Michael Buenor
N1 - Publisher Copyright:
© 2021 Ibrahim Luru Abdulai et al.
PY - 2021
Y1 - 2021
N2 - Background. Till date, there is no known antidote to cure diabetes mellitus despite the discovery and development of diverse pharmacotherapeutic agents many years ago. Technological advancement in natural product chemistry has led to the isolation of analogs of vitexin and isovitexin found in diverse bioresources. These compounds have been extensively studied to explore their pharmacological relevance in diabetes mellitus. Aim of the Study. The present review was to compile results from in vitro and in vivo studies performed with vitexin and isovitexin derivatives relating to diabetes mellitus and its complications. A systematic online literature query was executed to collect all relevant articles published up to March 2020. Results. In this piece, we have collected data and presented it in a one-stop document to support the multitargeted mechanistic actions of vitexin and isovitexin in controlling diabetes mellitus and its complications. Conclusion. Data collected hint that vitexin and isovitexin work by targeting diverse pathophysiological and metabolic pathways and molecular drug points involved in the clinical manifestations of diabetes mellitus. This is expected to provide a deeper understanding of its actions and also serve as a catapult for clinical trials and application research.
AB - Background. Till date, there is no known antidote to cure diabetes mellitus despite the discovery and development of diverse pharmacotherapeutic agents many years ago. Technological advancement in natural product chemistry has led to the isolation of analogs of vitexin and isovitexin found in diverse bioresources. These compounds have been extensively studied to explore their pharmacological relevance in diabetes mellitus. Aim of the Study. The present review was to compile results from in vitro and in vivo studies performed with vitexin and isovitexin derivatives relating to diabetes mellitus and its complications. A systematic online literature query was executed to collect all relevant articles published up to March 2020. Results. In this piece, we have collected data and presented it in a one-stop document to support the multitargeted mechanistic actions of vitexin and isovitexin in controlling diabetes mellitus and its complications. Conclusion. Data collected hint that vitexin and isovitexin work by targeting diverse pathophysiological and metabolic pathways and molecular drug points involved in the clinical manifestations of diabetes mellitus. This is expected to provide a deeper understanding of its actions and also serve as a catapult for clinical trials and application research.
UR - http://www.scopus.com/inward/record.url?scp=85104960856&partnerID=8YFLogxK
U2 - 10.1155/2021/6641128
DO - 10.1155/2021/6641128
M3 - Review article
C2 - 33935599
AN - SCOPUS:85104960856
SN - 2356-6140
VL - 2021
JO - Scientific World Journal
JF - Scientific World Journal
M1 - 6641128
ER -