TY - JOUR
T1 - Multinational, Multicenter Evaluation of Prostate Cancer Tissue in Sub-Saharan Africa
T2 - Challenges and Opportunities
AU - Van Wyk, Abraham C.
AU - Lal, Priti
AU - Ogunbiyi, J. Olufemi
AU - Kyokunda, Lynnette
AU - Hobenu, Fred
AU - Dial, Cherif
AU - Jalloh, Mohamed
AU - Gyasi, Richard
AU - Oluwole, Olabode P.
AU - Abrahams, Afua D.
AU - Botha, Adam R.
AU - Mtshali, Nompumelelo Zamokuhle
AU - Andrews, Caroline
AU - Mante, Sunny
AU - Adusei, Ben
AU - Gueye, Serigne M.
AU - Mensah, James E.
AU - Adjei, Andrew Anthony
AU - Tettey, Yao
AU - Adebiyi, Akin
AU - Aisuodionoe-Shadrach, Oseremen
AU - Eniola, Sefiu Bolarinwa
AU - Serna, Amparo
AU - Yamoah, Kosj
AU - Chen, Wenlong Carl
AU - Fernandez, Pedro
AU - Robinson, Brian D.
AU - Mosquera, Juan Miguel
AU - Hsing, Ann W.
AU - Agalliu, Ilir
AU - Rebbeck, Timothy R.
N1 - Publisher Copyright:
© 2024 American Society of Clinical Oncology.
PY - 2024
Y1 - 2024
N2 - PURPOSEProstate cancer disproportionately affects men of African descent, yet their representation in tissue-based studies is limited. This multinational, multicenter pilot study aims to establish the groundwork for collaborative research on prostate cancer in sub-Saharan Africa.METHODSThe Men of African Descent and Carcinoma of the Prostate network formed a pathologist working group representing eight institutions in five African countries. Formalin-fixed paraffin-embedded prostate tissue specimens were collected from Senegal, Nigeria, and Ghana. Histology slides were produced and digitally scanned. A central genitourinary pathologist (P.L.) and eight African general pathologists reviewed anonymized digital whole-slide images for International Society of Urological Pathology grade groups and other pathologic parameters. Discrepancies were re-evaluated, and consensus grading was assigned. A virtual training seminar on prostate cancer grading was followed by a second assessment on a subcohort of the same tissue set.RESULTSOf 134 tissue blocks, 133 had evaluable tissue; 13 lacked cancer evidence, and four were of insufficient quality. Post-training, interobserver agreement for grade groups improved to 56%, with a median Cohen's quadratic weighted kappa of 0.83 (mean, 0.74), compared with an initial 46% agreement and a quadratic weighted kappa of 0.77. Interobserver agreement between African pathologist groups was 40%, with a quadratic weighted kappa of 0.66 (95% CI, 0.51 to 0.76). African pathologists tended to overgrade (36%) more frequently than undergrade (18%) compared with the reference genitourinary pathologist. Interobserver variability tended to worsen with a decrease in tissue quality.CONCLUSIONTissue-based studies on prostate cancer in men of African descent are essential for a better understanding of this common disease. Standardized tissue handling protocols are crucial to ensure good tissue quality and data. The use of digital slide imaging can enhance collaboration among pathologists in multinational, multicenter studies.
AB - PURPOSEProstate cancer disproportionately affects men of African descent, yet their representation in tissue-based studies is limited. This multinational, multicenter pilot study aims to establish the groundwork for collaborative research on prostate cancer in sub-Saharan Africa.METHODSThe Men of African Descent and Carcinoma of the Prostate network formed a pathologist working group representing eight institutions in five African countries. Formalin-fixed paraffin-embedded prostate tissue specimens were collected from Senegal, Nigeria, and Ghana. Histology slides were produced and digitally scanned. A central genitourinary pathologist (P.L.) and eight African general pathologists reviewed anonymized digital whole-slide images for International Society of Urological Pathology grade groups and other pathologic parameters. Discrepancies were re-evaluated, and consensus grading was assigned. A virtual training seminar on prostate cancer grading was followed by a second assessment on a subcohort of the same tissue set.RESULTSOf 134 tissue blocks, 133 had evaluable tissue; 13 lacked cancer evidence, and four were of insufficient quality. Post-training, interobserver agreement for grade groups improved to 56%, with a median Cohen's quadratic weighted kappa of 0.83 (mean, 0.74), compared with an initial 46% agreement and a quadratic weighted kappa of 0.77. Interobserver agreement between African pathologist groups was 40%, with a quadratic weighted kappa of 0.66 (95% CI, 0.51 to 0.76). African pathologists tended to overgrade (36%) more frequently than undergrade (18%) compared with the reference genitourinary pathologist. Interobserver variability tended to worsen with a decrease in tissue quality.CONCLUSIONTissue-based studies on prostate cancer in men of African descent are essential for a better understanding of this common disease. Standardized tissue handling protocols are crucial to ensure good tissue quality and data. The use of digital slide imaging can enhance collaboration among pathologists in multinational, multicenter studies.
UR - http://www.scopus.com/inward/record.url?scp=85196137986&partnerID=8YFLogxK
U2 - 10.1200/GO.23.00403
DO - 10.1200/GO.23.00403
M3 - Article
C2 - 38870437
AN - SCOPUS:85196137986
SN - 2378-9506
VL - 10
JO - JCO Global Oncology
JF - JCO Global Oncology
M1 - e2300403
ER -
