TY - JOUR
T1 - Molecular Characterization of Circulating Yellow Fever Viruses from Outbreak in Ghana, 2021–2022
AU - Bonney, Joseph Humphrey Kofi
AU - Sanders, Terrel
AU - Pratt, Deborah
AU - Agbodzi, Bright
AU - Laryea, Dennis
AU - Agyeman, Nana Kwame Fredua
AU - Kumordjie, Selassie
AU - Attiku, Keren
AU - Adams, Patience Lartekai
AU - Boateng, Gideon Aning
AU - Ohene, Sally Ann
AU - Tamal, Christopher
AU - Mawuli, Gifty
AU - Yeboah, Clara
AU - Dadzie, Samuel
AU - Kubio, Chrysantus
AU - Asiedu-Bekoe, Franklin
AU - Odoom, John Kofi
N1 - Publisher Copyright:
© 2023 Centers for Disease Control and Prevention (CDC). All rights reserved.
PY - 2023/9
Y1 - 2023/9
N2 - Yellow fever virus, transmitted by infected Aedes spp. mosquitoes, causes an acute viral hemorrhagic disease. During October 2021–February 2022, a yellow fever outbreak in some communities in Ghana resulted in 70 confirmed cases with 35 deaths (case-fatality rate 50%). The outbreak started in a predominantly unvaccinated nomadic community in the Savannah region, from which 65% of the cases came. The molecular amplification methods we used for diagnosis produced full-length DNA sequences from 3 confirmed cases. Phylogenetic analysis characterized the 3 sequences within West Africa genotype II; strains shared a close homology with sequences from Cote d’Ivoire and Senegal. We deployed more sensitive advanced molecular diagnostic techniques, which enabled earlier detection, helped control spread, and improved case management. We urge increased efforts from health authorities to vaccinate vulnerable groups in difficult-to-access areas and to educate the population about potential risks for yellow fever infections.
AB - Yellow fever virus, transmitted by infected Aedes spp. mosquitoes, causes an acute viral hemorrhagic disease. During October 2021–February 2022, a yellow fever outbreak in some communities in Ghana resulted in 70 confirmed cases with 35 deaths (case-fatality rate 50%). The outbreak started in a predominantly unvaccinated nomadic community in the Savannah region, from which 65% of the cases came. The molecular amplification methods we used for diagnosis produced full-length DNA sequences from 3 confirmed cases. Phylogenetic analysis characterized the 3 sequences within West Africa genotype II; strains shared a close homology with sequences from Cote d’Ivoire and Senegal. We deployed more sensitive advanced molecular diagnostic techniques, which enabled earlier detection, helped control spread, and improved case management. We urge increased efforts from health authorities to vaccinate vulnerable groups in difficult-to-access areas and to educate the population about potential risks for yellow fever infections.
UR - http://www.scopus.com/inward/record.url?scp=85168787330&partnerID=8YFLogxK
U2 - 10.3201/eid2909.221671
DO - 10.3201/eid2909.221671
M3 - Article
C2 - 37610174
AN - SCOPUS:85168787330
SN - 1080-6040
VL - 29
SP - 1818
EP - 1826
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
IS - 9
ER -