Molecular Characterization of Circulating Yellow Fever Viruses from Outbreak in Ghana, 2021–2022

Joseph Humphrey Kofi Bonney, Terrel Sanders, Deborah Pratt, Bright Agbodzi, Dennis Laryea, Nana Kwame Fredua Agyeman, Selassie Kumordjie, Keren Attiku, Patience Lartekai Adams, Gideon Aning Boateng, Sally Ann Ohene, Christopher Tamal, Gifty Mawuli, Clara Yeboah, Samuel Dadzie, Chrysantus Kubio, Franklin Asiedu-Bekoe, John Kofi Odoom

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Yellow fever virus, transmitted by infected Aedes spp. mosquitoes, causes an acute viral hemorrhagic disease. During October 2021–February 2022, a yellow fever outbreak in some communities in Ghana resulted in 70 confirmed cases with 35 deaths (case-fatality rate 50%). The outbreak started in a predominantly unvaccinated nomadic community in the Savannah region, from which 65% of the cases came. The molecular amplification methods we used for diagnosis produced full-length DNA sequences from 3 confirmed cases. Phylogenetic analysis characterized the 3 sequences within West Africa genotype II; strains shared a close homology with sequences from Cote d’Ivoire and Senegal. We deployed more sensitive advanced molecular diagnostic techniques, which enabled earlier detection, helped control spread, and improved case management. We urge increased efforts from health authorities to vaccinate vulnerable groups in difficult-to-access areas and to educate the population about potential risks for yellow fever infections.

Original languageEnglish
Pages (from-to)1818-1826
Number of pages9
JournalEmerging Infectious Diseases
Volume29
Issue number9
DOIs
Publication statusPublished - Sep 2023
Externally publishedYes

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