Microvesicles in health and disease

Jameel M. Inal; Ephraim A. Ansa-Addo; Dan Stratton; Sharad Kholia; Samuel S. Antwi-Baffour; Samireh Jorfi; Sigrun Lange

doi:10.1007/s00005-012-0165-2

Microvesicles in health and disease

Jameel M. Inal, Ephraim A. Ansa-Addo, Dan Stratton, Sharad Kholia, Samuel S. Antwi-Baffour, Samireh Jorfi, Sigrun Lange

Research output: Contribution to journal › Review article › peer-review

57 Citations (Scopus)

Abstract

Microvesicles (or MVs) are plasma membrane-derived vesicles released from most eukaryotic cells constitutively during early apoptosis or at higher levels after chemical or physical stress conditions. This review looks at some of the functions of MVs in terms of intercellular communication and ensuant signal transduction, including the transport of proteins (unconventional protein export) as well as of mRNA and microRNA. MVs also have roles in membrane repair, the removal of misfolded proteins, and in the control of apoptosis. We also discuss the role MVs have been shown to have in invasive growth and metastasis as well as in hypoxia in tumours and cerebral ischaemia. The association of MVs in infectious and autoimmune disease is also summarised together with their possible use as therapeutic agents.

Original language	English
Pages (from-to)	107-121
Number of pages	15
Journal	Archivum Immunologiae et Therapiae Experimentalis
Volume	60
Issue number	2
DOIs	https://doi.org/10.1007/s00005-012-0165-2
Publication status	Published - Apr 2012
Externally published	Yes

Keywords

Autoimmune disease
Cancer
Infectious disease
Intercellular transport
Microvesicles
Stroke

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00005-012-0165-2

Cite this

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AU - Inal, Jameel M.

AU - Ansa-Addo, Ephraim A.

AU - Stratton, Dan

AU - Kholia, Sharad

AU - Antwi-Baffour, Samuel S.

AU - Jorfi, Samireh

AU - Lange, Sigrun

PY - 2012/4

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AB - Microvesicles (or MVs) are plasma membrane-derived vesicles released from most eukaryotic cells constitutively during early apoptosis or at higher levels after chemical or physical stress conditions. This review looks at some of the functions of MVs in terms of intercellular communication and ensuant signal transduction, including the transport of proteins (unconventional protein export) as well as of mRNA and microRNA. MVs also have roles in membrane repair, the removal of misfolded proteins, and in the control of apoptosis. We also discuss the role MVs have been shown to have in invasive growth and metastasis as well as in hypoxia in tumours and cerebral ischaemia. The association of MVs in infectious and autoimmune disease is also summarised together with their possible use as therapeutic agents.

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KW - Cancer

KW - Infectious disease

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KW - Stroke

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Microvesicles in health and disease

Abstract

Keywords

UN SDGs

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