TY - JOUR
T1 - Maternal HIV is associated with reduced growth in the first year of life among infants in the Eastern region of Ghana
T2 - The research to improve infant nutrition and growth (RIING) project
AU - Lartey, Anna
AU - Marquis, Grace S.
AU - Mazur, Robert
AU - Perez-Escamilla, Rafael
AU - Brakohiapa, Lucy
AU - Ampofo, William
AU - Sellen, Daniel
AU - Adu-Afarwuah, Seth
N1 - Publisher Copyright:
© 2012 John Wiley & Sons Ltd.
PY - 2014/10/1
Y1 - 2014/10/1
N2 - Children of HIV-infected mothers experience poor growth, but not much is understood about the extent to which such children are affected. The Research to Improve Infant Nutrition and Growth (RIING) Project used a longitudinal study design to investigate the association between maternal HIV status and growth among Ghanaian infants in the first year of life. Pregnant women in their third trimester were enrolled into three groups: HIV-negative (HIV-N, n=185), HIV-positive (HIV-P, n=190) and HIV-unknown (HIV-U, n=177). Socioeconomic data were collected. Infant weight and length were measured at birth and every month until 12 months of age. Weight-for-age (WAZ), weight-for-length (WLZ) and length-for-age (LAZ) z-scores were compared using analysis of covariance. Infant HIV status was not known as most mothers declined to test their children's status at 12 months. Adjusted mean WAZ and LAZ at birth were significantly higher for infants of HIV-N compared with infants of HIV-P mothers. The prevalence of underweight at 12 months in the HIV-N, HIV-P and HIV-U were 6.6%, 27.5% and 9.9% (P<0.05), respectively. By 12 months, the prevalence of stunting was significantly different (HIV-N=6.0%, HIV-P=26.5% and HIV-U=5.0%, P<0.05). The adjusted mean±SE LAZ (0.57±0.11 vs. -0.95±0.12; P<0.005) was significantly greater for infants of HIV-N mothers than infants of HIV-P mothers. Maternal HIV is associated with reduce infant growth in weight and length throughout the first year of life. Children of HIV-P mothers living in socioeconomically deprived communities need special support to mitigate any negative effect on growth performance.
AB - Children of HIV-infected mothers experience poor growth, but not much is understood about the extent to which such children are affected. The Research to Improve Infant Nutrition and Growth (RIING) Project used a longitudinal study design to investigate the association between maternal HIV status and growth among Ghanaian infants in the first year of life. Pregnant women in their third trimester were enrolled into three groups: HIV-negative (HIV-N, n=185), HIV-positive (HIV-P, n=190) and HIV-unknown (HIV-U, n=177). Socioeconomic data were collected. Infant weight and length were measured at birth and every month until 12 months of age. Weight-for-age (WAZ), weight-for-length (WLZ) and length-for-age (LAZ) z-scores were compared using analysis of covariance. Infant HIV status was not known as most mothers declined to test their children's status at 12 months. Adjusted mean WAZ and LAZ at birth were significantly higher for infants of HIV-N compared with infants of HIV-P mothers. The prevalence of underweight at 12 months in the HIV-N, HIV-P and HIV-U were 6.6%, 27.5% and 9.9% (P<0.05), respectively. By 12 months, the prevalence of stunting was significantly different (HIV-N=6.0%, HIV-P=26.5% and HIV-U=5.0%, P<0.05). The adjusted mean±SE LAZ (0.57±0.11 vs. -0.95±0.12; P<0.005) was significantly greater for infants of HIV-N mothers than infants of HIV-P mothers. Maternal HIV is associated with reduce infant growth in weight and length throughout the first year of life. Children of HIV-P mothers living in socioeconomically deprived communities need special support to mitigate any negative effect on growth performance.
KW - Birthweight
KW - Ghana
KW - HIV-infected mother
KW - Infant growth
UR - http://www.scopus.com/inward/record.url?scp=84907985652&partnerID=8YFLogxK
U2 - 10.1111/j.1740-8709.2012.00441.x
DO - 10.1111/j.1740-8709.2012.00441.x
M3 - Article
C2 - 22905700
AN - SCOPUS:84907985652
SN - 1740-8695
VL - 10
SP - 604
EP - 616
JO - Maternal and Child Nutrition
JF - Maternal and Child Nutrition
IS - 4
ER -