TY - JOUR
T1 - Malaria Vaccine Development
T2 - Focusing Field Erythrocyte Invasion Studies on Phenotypic Diversity: The West African Merozoite Invasion Network (WAMIN)
AU - The WAMIN consortium authors include (in alphabetical order):
AU - Ahouidi, Ambroise D.
AU - Amambua-Ngwa, Alfred
AU - Awandare, Gordon A.
AU - Bei, Amy K.
AU - Conway, David J.
AU - Diakite, Mahamadou
AU - Duraisingh, Manoj T.
AU - Rayner, Julian C.
AU - Zenonos, Zenon A.
N1 - Publisher Copyright:
© 2015 Elsevier Ltd
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Erythrocyte invasion by Plasmodium falciparum merozoites is an essential step for parasite survival and proliferation. Invasion is mediated by multiple ligands, which could be promising vaccine targets. The usage and sequence of these ligands differs between parasites, yet most studies of them have been carried out in only a few laboratory-adapted lines. To understand the true extent of natural variation in invasion phenotypes and prioritize vaccine candidates on a relevant evidence base, we need to develop and apply standardized assays to large numbers of field isolates. The West African Merozoite Invasion Network (WAMIN) has been formed to meet these goals, expand training in Plasmodium phenotyping, and perform large-scale field phenotyping studies in order to prioritize blood stage vaccine candidates.
AB - Erythrocyte invasion by Plasmodium falciparum merozoites is an essential step for parasite survival and proliferation. Invasion is mediated by multiple ligands, which could be promising vaccine targets. The usage and sequence of these ligands differs between parasites, yet most studies of them have been carried out in only a few laboratory-adapted lines. To understand the true extent of natural variation in invasion phenotypes and prioritize vaccine candidates on a relevant evidence base, we need to develop and apply standardized assays to large numbers of field isolates. The West African Merozoite Invasion Network (WAMIN) has been formed to meet these goals, expand training in Plasmodium phenotyping, and perform large-scale field phenotyping studies in order to prioritize blood stage vaccine candidates.
KW - alternative receptors
KW - antibody inhibition assays
KW - invasion
KW - malaria
KW - merozoite
KW - vaccine
UR - http://www.scopus.com/inward/record.url?scp=84966570141&partnerID=8YFLogxK
U2 - 10.1016/j.pt.2015.11.009
DO - 10.1016/j.pt.2015.11.009
M3 - Review article
C2 - 26725306
AN - SCOPUS:84966570141
SN - 1471-4922
VL - 32
SP - 274
EP - 283
JO - Trends in Parasitology
JF - Trends in Parasitology
IS - 4
ER -