Malaria Vaccine Development: Focusing Field Erythrocyte Invasion Studies on Phenotypic Diversity: The West African Merozoite Invasion Network (WAMIN)

The WAMIN consortium authors include (in alphabetical order):

Research output: Contribution to journalReview articlepeer-review

10 Citations (Scopus)

Abstract

Erythrocyte invasion by Plasmodium falciparum merozoites is an essential step for parasite survival and proliferation. Invasion is mediated by multiple ligands, which could be promising vaccine targets. The usage and sequence of these ligands differs between parasites, yet most studies of them have been carried out in only a few laboratory-adapted lines. To understand the true extent of natural variation in invasion phenotypes and prioritize vaccine candidates on a relevant evidence base, we need to develop and apply standardized assays to large numbers of field isolates. The West African Merozoite Invasion Network (WAMIN) has been formed to meet these goals, expand training in Plasmodium phenotyping, and perform large-scale field phenotyping studies in order to prioritize blood stage vaccine candidates.

Original languageEnglish
Pages (from-to)274-283
Number of pages10
JournalTrends in Parasitology
Volume32
Issue number4
DOIs
Publication statusPublished - 1 Apr 2016

Keywords

  • alternative receptors
  • antibody inhibition assays
  • invasion
  • malaria
  • merozoite
  • vaccine

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