Malaria artemisinin resistance: an extracellular vesicles export hypothesis

Kwesi Z. Tandoh; Collins M. Morang'a; Michael Wilson; Neils B. Quashie; Nancy O. Duah-Quashie

doi:10.1016/j.pt.2022.05.004

Malaria artemisinin resistance: an extracellular vesicles export hypothesis

Kwesi Z. Tandoh
, Collins M. Morang'a
, Michael Wilson
, Neils B. Quashie
, Nancy O. Duah-Quashie

University of Ghana
Noguchi Memorial Institute for Medical Research

Research output: Contribution to journal › Short survey › peer-review

8 Citations (Scopus)

Abstract

Plasmodium falciparum causes malaria, and its resistance to artemisinin (ART) – a drug used for managing malaria – threatens to interfere with the effective control of malaria. ART resistance (ARTr) is driven by increased tolerance to oxidative stress and reduced haemoglobin trafficking to the food vacuole. We discuss how extracellular vesicles (EVs) may play a role in developing ARTr.

Original language	English
Pages (from-to)	614-617
Number of pages	4
Journal	Trends in Parasitology
Volume	38
Issue number	8
DOIs	https://doi.org/10.1016/j.pt.2022.05.004
Publication status	Published - Aug 2022
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

artemisinin resistance
extracellular vesicles
hypothetical model

Access to Document

10.1016/j.pt.2022.05.004

Cite this

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title = "Malaria artemisinin resistance: an extracellular vesicles export hypothesis",

abstract = "Plasmodium falciparum causes malaria, and its resistance to artemisinin (ART) – a drug used for managing malaria – threatens to interfere with the effective control of malaria. ART resistance (ARTr) is driven by increased tolerance to oxidative stress and reduced haemoglobin trafficking to the food vacuole. We discuss how extracellular vesicles (EVs) may play a role in developing ARTr.",

keywords = "artemisinin resistance, extracellular vesicles, hypothetical model",

author = "Tandoh, \{Kwesi Z.\} and Morang'a, \{Collins M.\} and Michael Wilson and Quashie, \{Neils B.\} and Duah-Quashie, \{Nancy O.\}",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier Ltd",

year = "2022",

month = aug,

doi = "10.1016/j.pt.2022.05.004",

language = "English",

volume = "38",

pages = "614--617",

journal = "Trends in Parasitology",

issn = "1471-4922",

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TY - JOUR

T1 - Malaria artemisinin resistance

T2 - an extracellular vesicles export hypothesis

AU - Tandoh, Kwesi Z.

AU - Morang'a, Collins M.

AU - Wilson, Michael

AU - Quashie, Neils B.

AU - Duah-Quashie, Nancy O.

PY - 2022/8

Y1 - 2022/8

N2 - Plasmodium falciparum causes malaria, and its resistance to artemisinin (ART) – a drug used for managing malaria – threatens to interfere with the effective control of malaria. ART resistance (ARTr) is driven by increased tolerance to oxidative stress and reduced haemoglobin trafficking to the food vacuole. We discuss how extracellular vesicles (EVs) may play a role in developing ARTr.

AB - Plasmodium falciparum causes malaria, and its resistance to artemisinin (ART) – a drug used for managing malaria – threatens to interfere with the effective control of malaria. ART resistance (ARTr) is driven by increased tolerance to oxidative stress and reduced haemoglobin trafficking to the food vacuole. We discuss how extracellular vesicles (EVs) may play a role in developing ARTr.

KW - artemisinin resistance

KW - extracellular vesicles

KW - hypothetical model

UR - https://www.scopus.com/pages/publications/85131418878

U2 - 10.1016/j.pt.2022.05.004

DO - 10.1016/j.pt.2022.05.004

M3 - Short survey

C2 - 35661626

AN - SCOPUS:85131418878

SN - 1471-4922

VL - 38

SP - 614

EP - 617

JO - Trends in Parasitology

JF - Trends in Parasitology

IS - 8

ER -

Malaria artemisinin resistance: an extracellular vesicles export hypothesis

Abstract

UN SDGs

Keywords

Access to Document

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