TY - JOUR
T1 - Malaria artemisinin resistance
T2 - an extracellular vesicles export hypothesis
AU - Tandoh, Kwesi Z.
AU - Morang'a, Collins M.
AU - Wilson, Michael
AU - Quashie, Neils B.
AU - Duah-Quashie, Nancy O.
N1 - Publisher Copyright:
© 2022 Elsevier Ltd
PY - 2022/8
Y1 - 2022/8
N2 - Plasmodium falciparum causes malaria, and its resistance to artemisinin (ART) – a drug used for managing malaria – threatens to interfere with the effective control of malaria. ART resistance (ARTr) is driven by increased tolerance to oxidative stress and reduced haemoglobin trafficking to the food vacuole. We discuss how extracellular vesicles (EVs) may play a role in developing ARTr.
AB - Plasmodium falciparum causes malaria, and its resistance to artemisinin (ART) – a drug used for managing malaria – threatens to interfere with the effective control of malaria. ART resistance (ARTr) is driven by increased tolerance to oxidative stress and reduced haemoglobin trafficking to the food vacuole. We discuss how extracellular vesicles (EVs) may play a role in developing ARTr.
KW - artemisinin resistance
KW - extracellular vesicles
KW - hypothetical model
UR - http://www.scopus.com/inward/record.url?scp=85131418878&partnerID=8YFLogxK
U2 - 10.1016/j.pt.2022.05.004
DO - 10.1016/j.pt.2022.05.004
M3 - Short survey
C2 - 35661626
AN - SCOPUS:85131418878
SN - 1471-4922
VL - 38
SP - 614
EP - 617
JO - Trends in Parasitology
JF - Trends in Parasitology
IS - 8
ER -