TY - JOUR
T1 - Liver transplantation in patients with alcoholic liver disease
T2 - A retrospective study
AU - Gemelli OLT Group
AU - Vassallo, Gabriele A.
AU - Tarli, Claudia
AU - Rando, Maria M.
AU - Mosoni, Carolina
AU - Mirijello, Antonio
AU - Agyei-Nkansah, Adwoa
AU - Antonelli, Mariangela
AU - Sestito, Luisa
AU - Perotti, Germano
AU - Di Giuda, Daniela
AU - Agnes, Salvatore
AU - Grieco, Antonio
AU - Gasbarrini, Antonio
AU - Addolorato, Giovanni
AU - Abbate, Valeria
AU - Ainora, Maria Elena
AU - Annicchiarico, Eleonora
AU - Avolio, Alfonso Wolfango
AU - Biolato, Marco
AU - Calia, Rosaria
AU - de Matthaeis, Nicoletta
AU - Cristina d'Angelo, d'Angelo
AU - Ferrarese, Daniele
AU - Ferrulli, Anna
AU - Garcovich, Matteo
AU - Frongillo, Francesco
AU - Marrone, Giuseppe
AU - Miele, Luca
AU - Nure, Eda
AU - Pietrogiacomi, Paola
AU - Pizzolante, Fabrizio
AU - Pompili, Maurizio
AU - Ponziani, Francesca Romana
AU - Rapaccini, Gian Ludovico
AU - Riccardi, Laura
AU - Rinninella, Emanuele
AU - Sganga, Gabriele
AU - Siciliano, Massimo
AU - Zocco, Maria Assunta
N1 - Publisher Copyright:
© The Author 2017. Medical Council on Alcohol and Oxford University Press. All rights reserved.
PY - 2018/3/1
Y1 - 2018/3/1
N2 - Aim: Alcoholic liver disease (ALD) is the most common liver disease in the Western World. Liver transplantation (LT) is the treatment for end-stage ALD. However, many transplant centers are still reluctant to transplant these patients because of the risk of alcohol relapse, recurrence of the primary liver disease and associated post-transplant complications. We examined survival rate, prevalence of primary liver disease recurrence, re-transplantation and post-transplant complications among transplanted patients for alcoholic cirrhosis compared with those transplanted for viral cirrhosis. Methods: data about patients transplanted for alcoholic and viral cirrhosis at the Gemelli Hospital from January 1995 to April 2016 were retrospectively collected. Survival rate was evaluated according to the Kaplan-Meier method. Recurrence was defined as histological evidence of primary liver disease. Data on the onset of complication, causes of death and graft failure after liver transplant were analyzed. Results: There was no statistically significant difference regarding survival rate between the two groups. Only patients transplanted for viral cirrhosis presented with primary liver disease recurrence. There was a higher rate of cancer development in patients transplanted for alcoholic cirrhosis. Cancer was the major cause of death in this population. Risk factors associated with the onset of cancer were a high MELD score at the transplant time and smoking after transplantation. Conclusion: ALD is a good indication for LT. Patients transplanted for alcoholic cirrhosis should receive regular cancer screening and should be advised against smoking. Short Summary: No difference was found between patients transplanted for alcoholic cirrhosis and viral cirrhosis in term of survival rate. Only patients transplanted for viral cirrhosis presented primary liver disease recurrence. A higher rate of cancer development was found in patients transplanted for alcoholic cirrohosis. This complication was associated with post-trasplant smoking.
AB - Aim: Alcoholic liver disease (ALD) is the most common liver disease in the Western World. Liver transplantation (LT) is the treatment for end-stage ALD. However, many transplant centers are still reluctant to transplant these patients because of the risk of alcohol relapse, recurrence of the primary liver disease and associated post-transplant complications. We examined survival rate, prevalence of primary liver disease recurrence, re-transplantation and post-transplant complications among transplanted patients for alcoholic cirrhosis compared with those transplanted for viral cirrhosis. Methods: data about patients transplanted for alcoholic and viral cirrhosis at the Gemelli Hospital from January 1995 to April 2016 were retrospectively collected. Survival rate was evaluated according to the Kaplan-Meier method. Recurrence was defined as histological evidence of primary liver disease. Data on the onset of complication, causes of death and graft failure after liver transplant were analyzed. Results: There was no statistically significant difference regarding survival rate between the two groups. Only patients transplanted for viral cirrhosis presented with primary liver disease recurrence. There was a higher rate of cancer development in patients transplanted for alcoholic cirrhosis. Cancer was the major cause of death in this population. Risk factors associated with the onset of cancer were a high MELD score at the transplant time and smoking after transplantation. Conclusion: ALD is a good indication for LT. Patients transplanted for alcoholic cirrhosis should receive regular cancer screening and should be advised against smoking. Short Summary: No difference was found between patients transplanted for alcoholic cirrhosis and viral cirrhosis in term of survival rate. Only patients transplanted for viral cirrhosis presented primary liver disease recurrence. A higher rate of cancer development was found in patients transplanted for alcoholic cirrohosis. This complication was associated with post-trasplant smoking.
UR - http://www.scopus.com/inward/record.url?scp=85043484046&partnerID=8YFLogxK
U2 - 10.1093/alcalc/agx097
DO - 10.1093/alcalc/agx097
M3 - Article
C2 - 29206894
AN - SCOPUS:85043484046
SN - 0735-0414
VL - 53
SP - 151
EP - 156
JO - Alcohol and Alcoholism
JF - Alcohol and Alcoholism
IS - 2
ER -