Levels of anti-insulin antibodies in diabetic retinopathy patients: an observational cross-sectional study

Bismark N. Mohammed, Emmanuel K. Ofori, Christian N. Adekena, Seth K. Amponsah, Henry Asare-Anane, Seth D. Amanquah, Mubarak Abdul-Rahman, Kwesi N. Amissah-Arthur

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: This study evaluated the levels of anti-insulin antibodies (AIAs) and the influence of some antidiabetic medications on AIA in diabetes mellitus (DM) patients with retinopathy. Patient & methods: An observational cross-sectional study. Results: A lower titer of AIA IgG was observed in the diabetic retinopathy (DR) and DM-only study categories compared with the control group [DR = 86 (5–560), DM-only = 50 (5–500), versus control = 200 (7–565); p = 0.017]. Taking nifedipine and metformin were negatively correlated (r = -0.32, p = 0.04) with the levels of AIA IgE in the DR group. Conclusion: A decreased titer of circulating AIAs was observed in the DR study category, suggesting that AIA may not contribute to the pathogenesis of DR.

Original languageEnglish
Article numberFSO982
JournalFuture Science OA
Volume10
Issue number1
DOIs
Publication statusPublished - 2024

Keywords

  • autoantibodies
  • diabetes mellitus
  • glycemia
  • insulin
  • retinopathy

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