Abstract
Aim: This study evaluated the levels of anti-insulin antibodies (AIAs) and the influence of some antidiabetic medications on AIA in diabetes mellitus (DM) patients with retinopathy. Patient & methods: An observational cross-sectional study. Results: A lower titer of AIA IgG was observed in the diabetic retinopathy (DR) and DM-only study categories compared with the control group [DR = 86 (5–560), DM-only = 50 (5–500), versus control = 200 (7–565); p = 0.017]. Taking nifedipine and metformin were negatively correlated (r = -0.32, p = 0.04) with the levels of AIA IgE in the DR group. Conclusion: A decreased titer of circulating AIAs was observed in the DR study category, suggesting that AIA may not contribute to the pathogenesis of DR.
Original language | English |
---|---|
Article number | FSO982 |
Journal | Future Science OA |
Volume | 10 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2024 |
Keywords
- autoantibodies
- diabetes mellitus
- glycemia
- insulin
- retinopathy