Abstract
Lassa fever, caused by the Lassa virus, is an acute viral hemorrhagic illness that is a public health challenge in West Africa. There have been several outbreaks of Lassa fever, and these have been associated with high morbidity and mortality. The clinical presentation of Lassa fever is diverse, ranging from mild febrile illness to severe multi-organ dysfunction. Diagnostic methods, including laboratory testing, serological assays, polymerase chain reaction (PCR), and imaging techniques are essential for accurate and timely diagnosis of this disease. Management and treatment options for Lassa fever include supportive care, antiviral therapy (ribavirin), experimental therapies, and immune-based therapies. This chapter provides an update on recent clinical reports and management strategies for Lassa fever. The geographical distribution of Lassa fever, its mode of transmission, reservoir hosts, and the incidence and prevalence of the disease are discussed. The chapter also highlights future prospects and research directions, including vaccine development, therapeutic interventions, improved diagnostic tools, enhanced surveillance systems, and an understanding of viral pathogenesis. The challenges and opportunities in Lassa fever management are addressed, emphasizing the need for collaboration, funding, and resource allocation. A call to action is made to strengthen healthcare systems, improve access to diagnosis and treatment, enhance surveillance, and prioritize community engagement. By addressing these aspects collectively, significant progress can be made in mitigating the impact of Lassa fever and preventing future outbreaks, ultimately protecting the health and well-being of affected communities.
Original language | English |
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Title of host publication | Rising Contagious Diseases |
Subtitle of host publication | Basics, Management, and Treatments |
Publisher | wiley |
Pages | 199-206 |
Number of pages | 8 |
ISBN (Electronic) | 9781394188741 |
ISBN (Print) | 9781394188710 |
DOIs | |
Publication status | Published - 1 Jan 2024 |
Keywords
- Lassa fever
- Lassa virus
- management strategies
- recent clinical reports