Lassa Fever: Recent Clinical Reports and Management Update

Abigail Aning, Kwasi A. Bugyei, Bismarck A. Hottor, Seth K. Amponsah

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Lassa fever, caused by the Lassa virus, is an acute viral hemorrhagic illness that is a public health challenge in West Africa. There have been several outbreaks of Lassa fever, and these have been associated with high morbidity and mortality. The clinical presentation of Lassa fever is diverse, ranging from mild febrile illness to severe multi-organ dysfunction. Diagnostic methods, including laboratory testing, serological assays, polymerase chain reaction (PCR), and imaging techniques are essential for accurate and timely diagnosis of this disease. Management and treatment options for Lassa fever include supportive care, antiviral therapy (ribavirin), experimental therapies, and immune-based therapies. This chapter provides an update on recent clinical reports and management strategies for Lassa fever. The geographical distribution of Lassa fever, its mode of transmission, reservoir hosts, and the incidence and prevalence of the disease are discussed. The chapter also highlights future prospects and research directions, including vaccine development, therapeutic interventions, improved diagnostic tools, enhanced surveillance systems, and an understanding of viral pathogenesis. The challenges and opportunities in Lassa fever management are addressed, emphasizing the need for collaboration, funding, and resource allocation. A call to action is made to strengthen healthcare systems, improve access to diagnosis and treatment, enhance surveillance, and prioritize community engagement. By addressing these aspects collectively, significant progress can be made in mitigating the impact of Lassa fever and preventing future outbreaks, ultimately protecting the health and well-being of affected communities.

Original languageEnglish
Title of host publicationRising Contagious Diseases
Subtitle of host publicationBasics, Management, and Treatments
Publisherwiley
Pages199-206
Number of pages8
ISBN (Electronic)9781394188741
ISBN (Print)9781394188710
DOIs
Publication statusPublished - 1 Jan 2024

Keywords

  • Lassa fever
  • Lassa virus
  • management strategies
  • recent clinical reports

Fingerprint

Dive into the research topics of 'Lassa Fever: Recent Clinical Reports and Management Update'. Together they form a unique fingerprint.

Cite this