TY - JOUR
T1 - K13-propeller polymorphisms in plasmodium falciparum parasites from sub-saharan Africa
AU - Kamau, Edwin
AU - Campino, Susana
AU - Amenga-Etego, Lucas
AU - Drury, Eleanor
AU - Ishengoma, Deus
AU - Johnson, Kimberly
AU - Mumba, Dieudonne
AU - Kekre, Mihir
AU - Yavo, William
AU - Mead, Daniel
AU - Bouyou-Akotet, Marielle
AU - Apinjoh, Tobias
AU - Golassa, Lemu
AU - Randrianarivelojosia, Milijaona
AU - Andagalu, Ben
AU - Maiga-Ascofare, Oumou
AU - Amambua-Ngwa, Alfred
AU - Tindana, Paulina
AU - Ghansah, Anita
AU - Macinnis, Bronwyn
AU - Kwiatkowski, Dominic
AU - Djimde, Abdoulaye A.
N1 - Publisher Copyright:
© 2015 The Author. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.
PY - 2015/4/15
Y1 - 2015/4/15
N2 - Mutations in the Plasmodium falciparum K13-propeller domain have recently been shown to be important determinants of artemisinin resistance in Southeast Asia. This study investigated the prevalence of K13-propeller polymorphisms across sub-Saharan Africa. A total of 1212 P. falciparum samples collected from 12 countries were sequenced. None of the K13-propeller mutations previously reported in Southeast Asia were found, but 22 unique mutations were detected, of which 7 were nonsynonymous. Allele frequencies ranged between 1% and 3%. Three mutations were observed in >1 country, and the A578S was present in parasites from 5 countries. This study provides the baseline prevalence of K13-propeller mutations in sub-Saharan Africa.
AB - Mutations in the Plasmodium falciparum K13-propeller domain have recently been shown to be important determinants of artemisinin resistance in Southeast Asia. This study investigated the prevalence of K13-propeller polymorphisms across sub-Saharan Africa. A total of 1212 P. falciparum samples collected from 12 countries were sequenced. None of the K13-propeller mutations previously reported in Southeast Asia were found, but 22 unique mutations were detected, of which 7 were nonsynonymous. Allele frequencies ranged between 1% and 3%. Three mutations were observed in >1 country, and the A578S was present in parasites from 5 countries. This study provides the baseline prevalence of K13-propeller mutations in sub-Saharan Africa.
KW - K13-propeller
KW - artemisinin resistance
KW - sub-Saharan Africa
UR - https://www.scopus.com/pages/publications/84926625655
U2 - 10.1093/infdis/jiu608
DO - 10.1093/infdis/jiu608
M3 - Article
C2 - 25367300
AN - SCOPUS:84926625655
SN - 0022-1899
VL - 211
SP - 1352
EP - 1355
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 8
ER -
