K13-propeller polymorphisms in plasmodium falciparum parasites from sub-saharan Africa

Edwin Kamau; Susana Campino; Lucas Amenga-Etego; Eleanor Drury; Deus Ishengoma; Kimberly Johnson; Dieudonne Mumba; Mihir Kekre; William Yavo; Daniel Mead; Marielle Bouyou-Akotet; Tobias Apinjoh; Lemu Golassa; Milijaona Randrianarivelojosia; Ben Andagalu; Oumou Maiga-Ascofare; Alfred Amambua-Ngwa; Paulina Tindana; Anita Ghansah; Bronwyn Macinnis; Dominic Kwiatkowski; Abdoulaye A. Djimde

doi:10.1093/infdis/jiu608

K13-propeller polymorphisms in plasmodium falciparum parasites from sub-saharan Africa

Edwin Kamau, Susana Campino, Lucas Amenga-Etego, Eleanor Drury, Deus Ishengoma, Kimberly Johnson, Dieudonne Mumba, Mihir Kekre, William Yavo, Daniel Mead, Marielle Bouyou-Akotet, Tobias Apinjoh, Lemu Golassa, Milijaona Randrianarivelojosia, Ben Andagalu, Oumou Maiga-Ascofare, Alfred Amambua-Ngwa, Paulina Tindana, Anita Ghansah, Bronwyn MacinnisDominic Kwiatkowski, Abdoulaye A. Djimde

West African Center for Cell Biology of Infectious Pathogens

Research output: Contribution to journal › Article › peer-review

195 Citations (Scopus)

Abstract

Mutations in the Plasmodium falciparum K13-propeller domain have recently been shown to be important determinants of artemisinin resistance in Southeast Asia. This study investigated the prevalence of K13-propeller polymorphisms across sub-Saharan Africa. A total of 1212 P. falciparum samples collected from 12 countries were sequenced. None of the K13-propeller mutations previously reported in Southeast Asia were found, but 22 unique mutations were detected, of which 7 were nonsynonymous. Allele frequencies ranged between 1% and 3%. Three mutations were observed in >1 country, and the A578S was present in parasites from 5 countries. This study provides the baseline prevalence of K13-propeller mutations in sub-Saharan Africa.

Original language	English
Pages (from-to)	1352-1355
Number of pages	4
Journal	Journal of Infectious Diseases
Volume	211
Issue number	8
DOIs	https://doi.org/10.1093/infdis/jiu608
Publication status	Published - 15 Apr 2015

Keywords

K13-propeller
artemisinin resistance
sub-Saharan Africa

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/infdis/jiu608

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Kamau, E., Campino, S., Amenga-Etego, L., Drury, E., Ishengoma, D., Johnson, K., Mumba, D., Kekre, M., Yavo, W., Mead, D., Bouyou-Akotet, M., Apinjoh, T., Golassa, L., Randrianarivelojosia, M., Andagalu, B., Maiga-Ascofare, O., Amambua-Ngwa, A., Tindana, P., Ghansah, A., ... Djimde, A. A. (2015). K13-propeller polymorphisms in plasmodium falciparum parasites from sub-saharan Africa. Journal of Infectious Diseases, 211(8), 1352-1355. https://doi.org/10.1093/infdis/jiu608

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title = "K13-propeller polymorphisms in plasmodium falciparum parasites from sub-saharan Africa",

abstract = "Mutations in the Plasmodium falciparum K13-propeller domain have recently been shown to be important determinants of artemisinin resistance in Southeast Asia. This study investigated the prevalence of K13-propeller polymorphisms across sub-Saharan Africa. A total of 1212 P. falciparum samples collected from 12 countries were sequenced. None of the K13-propeller mutations previously reported in Southeast Asia were found, but 22 unique mutations were detected, of which 7 were nonsynonymous. Allele frequencies ranged between 1% and 3%. Three mutations were observed in >1 country, and the A578S was present in parasites from 5 countries. This study provides the baseline prevalence of K13-propeller mutations in sub-Saharan Africa.",

keywords = "K13-propeller, artemisinin resistance, sub-Saharan Africa",

author = "Edwin Kamau and Susana Campino and Lucas Amenga-Etego and Eleanor Drury and Deus Ishengoma and Kimberly Johnson and Dieudonne Mumba and Mihir Kekre and William Yavo and Daniel Mead and Marielle Bouyou-Akotet and Tobias Apinjoh and Lemu Golassa and Milijaona Randrianarivelojosia and Ben Andagalu and Oumou Maiga-Ascofare and Alfred Amambua-Ngwa and Paulina Tindana and Anita Ghansah and Bronwyn Macinnis and Dominic Kwiatkowski and Djimde, {Abdoulaye A.}",

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doi = "10.1093/infdis/jiu608",

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Kamau, E, Campino, S, Amenga-Etego, L, Drury, E, Ishengoma, D, Johnson, K, Mumba, D, Kekre, M, Yavo, W, Mead, D, Bouyou-Akotet, M, Apinjoh, T, Golassa, L, Randrianarivelojosia, M, Andagalu, B, Maiga-Ascofare, O, Amambua-Ngwa, A, Tindana, P, Ghansah, A, Macinnis, B, Kwiatkowski, D & Djimde, AA 2015, 'K13-propeller polymorphisms in plasmodium falciparum parasites from sub-saharan Africa', Journal of Infectious Diseases, vol. 211, no. 8, pp. 1352-1355. https://doi.org/10.1093/infdis/jiu608

TY - JOUR

T1 - K13-propeller polymorphisms in plasmodium falciparum parasites from sub-saharan Africa

AU - Kamau, Edwin

AU - Campino, Susana

AU - Amenga-Etego, Lucas

AU - Drury, Eleanor

AU - Ishengoma, Deus

AU - Johnson, Kimberly

AU - Mumba, Dieudonne

AU - Kekre, Mihir

AU - Yavo, William

AU - Mead, Daniel

AU - Bouyou-Akotet, Marielle

AU - Apinjoh, Tobias

AU - Golassa, Lemu

AU - Randrianarivelojosia, Milijaona

AU - Andagalu, Ben

AU - Maiga-Ascofare, Oumou

AU - Amambua-Ngwa, Alfred

AU - Tindana, Paulina

AU - Ghansah, Anita

AU - Macinnis, Bronwyn

AU - Kwiatkowski, Dominic

AU - Djimde, Abdoulaye A.

PY - 2015/4/15

Y1 - 2015/4/15

N2 - Mutations in the Plasmodium falciparum K13-propeller domain have recently been shown to be important determinants of artemisinin resistance in Southeast Asia. This study investigated the prevalence of K13-propeller polymorphisms across sub-Saharan Africa. A total of 1212 P. falciparum samples collected from 12 countries were sequenced. None of the K13-propeller mutations previously reported in Southeast Asia were found, but 22 unique mutations were detected, of which 7 were nonsynonymous. Allele frequencies ranged between 1% and 3%. Three mutations were observed in >1 country, and the A578S was present in parasites from 5 countries. This study provides the baseline prevalence of K13-propeller mutations in sub-Saharan Africa.

AB - Mutations in the Plasmodium falciparum K13-propeller domain have recently been shown to be important determinants of artemisinin resistance in Southeast Asia. This study investigated the prevalence of K13-propeller polymorphisms across sub-Saharan Africa. A total of 1212 P. falciparum samples collected from 12 countries were sequenced. None of the K13-propeller mutations previously reported in Southeast Asia were found, but 22 unique mutations were detected, of which 7 were nonsynonymous. Allele frequencies ranged between 1% and 3%. Three mutations were observed in >1 country, and the A578S was present in parasites from 5 countries. This study provides the baseline prevalence of K13-propeller mutations in sub-Saharan Africa.

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KW - artemisinin resistance

KW - sub-Saharan Africa

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M3 - Article

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AN - SCOPUS:84926625655

SN - 0022-1899

VL - 211

SP - 1352

EP - 1355

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 8

ER -

K13-propeller polymorphisms in plasmodium falciparum parasites from sub-saharan Africa

Abstract

Keywords

UN SDGs

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