TY - JOUR
T1 - Intravitreal Ziv-Aflibercept
T2 - Safety Analysis in Eyes Receiving More Than Ten Intravitreal Injections
AU - Singh, Sumit Randhir
AU - Chattannavar, Goura
AU - Ayachit, Apoorva
AU - Pimentel, Miguel Cruz
AU - Alfaro, Alex
AU - Tiwari, Sarvesh
AU - Heranjal, Abhishek
AU - Subramanyam, Anand
AU - Braimah, Imoro Zeba
AU - Dhami, Abhinav
AU - Sachdev, Parineeta
AU - Mansour, Ahmad
AU - Chhablani, Jay
N1 - Publisher Copyright:
©, © Taylor & Francis.
PY - 2020/1/2
Y1 - 2020/1/2
N2 - Purpose: To report the ocular and systemic adverse events in eyes receiving ≥10 intravitreal ziv-aflibercept (IVZ) injections. Methods: Medical records of patients who received ≥10 IVZ for various chorioretinal conditions with minimum follow up period of 12 months were retrospectively analysed. These eyes received standard dose of IVZ (1.25 mg/0.05 ml) on pro-re-nata (PRN) or treat and extend (T&E) protocol. The primary study outcome was ocular and systemic adverse events related to IVZ injections whereas secondary outcomes were change in best corrected visual acuity (BCVA) and central macular thickness (CMT) on optical coherence tomography (OCT) at last visit compared to baseline. Comparison of BCVA and CMT at baseline and final visit was done using paired t-test. Results: A total of 94 eyes which received a mean ± standard deviation (mean±SD = 14.4 ± 4.6) IVZ injections were studied. A total of 41 eyes were treatment naïve whereas 53 eyes received intravitreal injections in the past with last injection at least 3 months prior. Mean (±SD) follow up period was 26.7 ± 8.7 months. Ocular adverse events were limited with a case each of acute iridocyclitis, endophthalmitis, cataract progression and early epiretinal membrane formation. No systemic events were recorded within a month of IVZ injection. There was a significant improvement in BCVA (p = 0.001) and change in CMT (p = 0.001) at last visit. Conclusion: Ocular use of ziv-aflibercept is safe with limited ocular and systemic side effects. Multiple injections of IVZ can be used in various chorioretinal diseases over the long term.
AB - Purpose: To report the ocular and systemic adverse events in eyes receiving ≥10 intravitreal ziv-aflibercept (IVZ) injections. Methods: Medical records of patients who received ≥10 IVZ for various chorioretinal conditions with minimum follow up period of 12 months were retrospectively analysed. These eyes received standard dose of IVZ (1.25 mg/0.05 ml) on pro-re-nata (PRN) or treat and extend (T&E) protocol. The primary study outcome was ocular and systemic adverse events related to IVZ injections whereas secondary outcomes were change in best corrected visual acuity (BCVA) and central macular thickness (CMT) on optical coherence tomography (OCT) at last visit compared to baseline. Comparison of BCVA and CMT at baseline and final visit was done using paired t-test. Results: A total of 94 eyes which received a mean ± standard deviation (mean±SD = 14.4 ± 4.6) IVZ injections were studied. A total of 41 eyes were treatment naïve whereas 53 eyes received intravitreal injections in the past with last injection at least 3 months prior. Mean (±SD) follow up period was 26.7 ± 8.7 months. Ocular adverse events were limited with a case each of acute iridocyclitis, endophthalmitis, cataract progression and early epiretinal membrane formation. No systemic events were recorded within a month of IVZ injection. There was a significant improvement in BCVA (p = 0.001) and change in CMT (p = 0.001) at last visit. Conclusion: Ocular use of ziv-aflibercept is safe with limited ocular and systemic side effects. Multiple injections of IVZ can be used in various chorioretinal diseases over the long term.
KW - Diabetic macular edema (DME)
KW - Intravitreal ziv, aflibercept (IVZ)
KW - Neovascular age related macular degeneration (n, AMD)
KW - Ziv, aflibercept
KW - retinal venous occlusion (RVO)
UR - http://www.scopus.com/inward/record.url?scp=85074844755&partnerID=8YFLogxK
U2 - 10.1080/08820538.2019.1686528
DO - 10.1080/08820538.2019.1686528
M3 - Article
C2 - 31690175
AN - SCOPUS:85074844755
SN - 0882-0538
VL - 35
SP - 2
EP - 6
JO - Seminars in Ophthalmology
JF - Seminars in Ophthalmology
IS - 1
ER -