TY - JOUR
T1 - Infant feeding options, other nonchemoprophylactic factors, and mother-to-child transmission of HIV in Zambia
AU - Torpey, Kwasi
AU - Kabaso, Mushota
AU - Weaver, Mark A.
AU - Kasonde, Prisca
AU - Mukonka, Victor
AU - Bweupe, Maximillian
AU - Mukundu, Jonathan
AU - Mandala, Justin
PY - 2012/1
Y1 - 2012/1
N2 - Background: The role of antiretroviral drugs in the prevention of mother-to-child transmission (PMTCT) of HIV is well known. The objective of this study is to explore how nonchemoprophylactic factors, including infant feeding practices, mother's HIV status disclosure, mode and place of delivery, infant gender, and maternal age, are related to MTCT. Methods: The study analyzed program data of DNA polymerase chain reaction (PCR) results from dried blood spot samples and selected client information from perinatally exposed infants aged 0 to 12 months. Results: A total of 8237 samples were analyzed. In all, 84% of the mothers ever breast-fed their children. In instances where both mother and baby received intervention, the transmission rates of HIV were higher among those who are still breast-feeding after 6 to 12 months. Disclosure, location, and mode of delivery did not have an effect on the transmission rates of HIV when both mother and baby received prophylaxis. Conclusion: Nonchemoprophylaxis factors, especially breast-feeding, play a key role in perinatal transmission of HIV.
AB - Background: The role of antiretroviral drugs in the prevention of mother-to-child transmission (PMTCT) of HIV is well known. The objective of this study is to explore how nonchemoprophylactic factors, including infant feeding practices, mother's HIV status disclosure, mode and place of delivery, infant gender, and maternal age, are related to MTCT. Methods: The study analyzed program data of DNA polymerase chain reaction (PCR) results from dried blood spot samples and selected client information from perinatally exposed infants aged 0 to 12 months. Results: A total of 8237 samples were analyzed. In all, 84% of the mothers ever breast-fed their children. In instances where both mother and baby received intervention, the transmission rates of HIV were higher among those who are still breast-feeding after 6 to 12 months. Disclosure, location, and mode of delivery did not have an effect on the transmission rates of HIV when both mother and baby received prophylaxis. Conclusion: Nonchemoprophylaxis factors, especially breast-feeding, play a key role in perinatal transmission of HIV.
KW - Breast-feeding
KW - Zambia
KW - disclosure
KW - nonchemoprophylactic
KW - prevention of mother-to-child transmission
UR - http://www.scopus.com/inward/record.url?scp=84856890024&partnerID=8YFLogxK
U2 - 10.1177/1545109710393308
DO - 10.1177/1545109710393308
M3 - Article
C2 - 21430237
AN - SCOPUS:84856890024
SN - 1545-1097
VL - 11
SP - 26
EP - 33
JO - Journal of the International Association of Physicians in AIDS Care
JF - Journal of the International Association of Physicians in AIDS Care
IS - 1
ER -
